摘要
目的:探讨HER-2/neu和RECK蛋白在乳腺癌组织中的表达及其临床意义。方法:采用SP法,对76例乳腺癌组织标本及30例正常乳腺组织标本进行免疫组化检测,观察乳腺癌组织及正常乳腺组织中HER-2/neu和RECK蛋白表达情况,并比较不同TNM分期、病理分化程度乳腺癌组织HER-2/neu和RECK蛋白表达强度及阳性率差异,分析其两者之间的关系。结果:乳腺癌组织HER-2/neu表达强度及阳性率高于正常乳腺组织,RECK表达强度及阳性率低于正常乳腺组织,乳腺癌组织中HER-2/neu和RECK表达强度及阳性率同TNM分期及肿瘤组织分化具有相关性,乳腺癌组织HER-2/neu和RECK表达呈负相关。结论:乳腺癌组织中HER-2/neu过度表达、RECK表达减弱或缺失的现象,可能是乳腺癌发生、发展的生物学机制之一。
Objective：To investigate the expression and clinical significance of HER-2/neu and RECK in breast carcinoma tissue.Methods：A total of 76 cases of breast carcinoma tissue and 30 cases of normal breast tissue were selected and stained with SP immunohistochemical method to detect the expression of HER-2/neu and RECK,positive rate and intensity were compared among cases with different TNM stage and differentiation of breast carcinoma,correlation between HER-2/neu and RECK was analyzed in breast carcinoma tissue.Results：Positive rate and intensity of HER-2/neu were higher and RECK were lower in breast carcinoma tissue than those in normal breast tissue,which were correlative with TNM stage and differentiation of breast carcinoma,the expression of HER-2/neu was negatively correlated with RECK in breast carcinoma tissue.Conclusion：HER-2/neu was over expressed while RECK was not expressed or at a low level in breast carcinoma tissue,these might be a biological mechanism for the occurrence and progression of breast carcinoma.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2012年第9期1237-1240,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
南京医科大学附属江苏省肿瘤医院科研基金(ZM200802)
