摘要
目的检测并分析尘肺患者血清中白细胞介素-6和C-反应蛋白含量变化,为尘肺病的诊断、分期以及防治工作提供依据。方法采用免疫透射比浊法对住院不同期别尘肺患者(病例组)94例以及未接触过粉尘作业门诊体检人员(对照组)30人进行白细胞介素-6和C-反应蛋白的测定和分析。结果与对照组相比,尘肺患者血清中白细胞介素-6与C-反应蛋白水平均明显升高(P<0.05);与对照组相比,Ⅰ期、Ⅱ期、Ⅲ期尘肺患者白细胞介素-6和C-反应蛋白含量有递增的趋势,各组间差异有统计学意义(P<0.05)。结论尘肺患者血清中白细胞介素-6和C-反应蛋白升高对尘肺患者临床诊断、分期,预后以及尘肺病发病机理的探讨有一定的意义。
Objective To investigate the changes of IL-6 and C-reactive protein（CRP） levels in the serum of pneumoco niosis patients.Method Immunity transmission turbidity was applied to detect the IL-6 and CRP levels in 94 pneumoconio sis patients at different stages and other 30 control blood samples from physical examination.Results Compared with control,both the IL-6 and CRP levels in 94 pneumoconiosis patients were elevated significantly（P0.05）.IL-6 and CRP levels in pneumoconiosis patients showed a gradually increasing trend at stage I,II and III.The difference of IL-6 and CRP levels were statistically and significantly different at stage I,II and III respectively.Conclusion Elevated IL-6 and CRP levels in serum of pneumoconiosis patients are of great importannce for diagnosis of pneumoconiosis,clinical phasing,prognosis and elucidat ing mechanisms.
出处
《中国热带医学》
CAS
2012年第9期1125-1126,共2页
China Tropical Medicine
