摘要
目的:探讨胎膜早破及其绒膜羊膜炎时孕妇血和脐血白细胞介素-8(interleukin-8,IL-8)的意义。方法:采用放射免疫法对30例胎膜早破孕妇血和脐血进行IL-8的测定,并以正常足月妊娠孕妇20例做对照。组织绒膜羊膜炎通过产后胎盘病理确诊。结果:胎膜早破孕妇血和脐血IL-8的水平明显高于对照组(P<0.01～0.02),随着破膜时间延长IL-8升高,且时间超过30小时IL-8明显升高,绒膜羊膜炎患者孕妇血和脐血IL-8与非绒膜羊膜炎比较,有显著差异(P<0.001)孕妇血和脐血IL-8的变化与产力无关(P>0.05),两组孕妇血和脐血IL-8水平呈正相关(P<0.001)。结论:孕妇血IL-8的浓度可作为足月胎膜早破组织绒膜羊膜炎筛选的一个指标。
Objective: To investigate the significance of 1L - 8 levels in maternal and cord serum with premature rupture of membranes (PROM) and chorioam-nionitis. Method:30 pregnant women with PROM at term and 20 normal pregant women at term were enrolled. Maternal and cord serum IL-8 were measured by radioimmunoassay. Chorioamnionitis was histopathologically confirmed after delivery. Result IL-8 levels of maternal and cord serum in PROM group were higher than those of the control group(P <0. 02, P<0. 01). IL-8 levels of maternal and cord serum were increased with proion gation of time for PROM, and more significantly increaed beyord 30 hours. The sera of maternal and cord with histologi-cal chorioamnionitis showed a significant increase in IL-8 levels than those without chorioamnionitis (P< 0. 001). There were no significant difference between the sera of maternal serum and cord IL-8 and labor (P>0. 05). There was a significant positive correlation between the maternal serum and cord serum IL-8 levels(P<0. 001). Conclusion:Measurement of maternal serum IL-8 can be used as a marker for screeing histological chorioamnionitis with premature rupture of membranes at term.
出处
《中国计划生育学杂志》
2000年第6期249-251,共3页
Chinese Journal of Family Planning
基金
河北省科委赞助
关键词
绒膜羊膜炎
胎膜早破
孕妇血
IL-8
Chorioamnionitis Premature rupture of membrane IL-8 Maternal serum Cord serum
