摘要
目的采用红外光谱法对草乌原药材、不同程度水炮制品种提取物进行分析，观察草乌炮制过程中主要毒性成分的变化。方法采用傅立叶变换红外光谱法，研究草乌原药材、不同程度水炮制品种的红外光谱特征。结果①由乌头碱和次乌头碱的红外谱图得知1717cm-1、1727cm-l和1711cm-1是C=O伸缩振动峰，是双酯型生物碱的特征峰；②所有的水泡样品虽吸收峰有一定变化，但仍存在双酯型生物碱吸收峰，说明水解不完全；③水煮草乌炮制法，在水煮样品中双酯型生物碱的吸收峰发生位移。结论草乌中双酯型生物碱与水泡时间的长短呈正相关。
Objective Infrared spectroscopy was used to study on both raw material and different degree water processing varieties extract of Radix Aconiti kusnezoffii, to observe the changes of main toxic components in processing, and thus to improve the quality of Radix Aconiti kusnezoffii processed products. Methods Fu Liye transform infrared spectroscopy was adopted to study the infrared spectrum characteristic of raw materials and different degree water processing varieties of. Radix Aconiti kusnezoffii. Results （1） Aconitine and hypaconitine infrared spectrum showed that 1717 cm 1, 1727 cm-1 and 1711 cm-1 is the C=O stretching vibration peak. It is a diester alkaloids characteristic peaks; （2） although absorption peak of all vesicular samples had a certain change, it still existed diester alkaloids absorption peak, indicating the incomplete hydrolysis; （3） boiled aconite processing methods demonstrated diester alkaloids absorption peak shift in the water sample. Conclusion Diester alkaloids in Radix Aconiti kusnezoffii shows a positive relation with its time soaked in water.
出处
《国际中医中药杂志》
2012年第11期1000-1003,共4页
International Journal of Traditional Chinese Medicine
基金
北京中医药大学自主课题（项目编号：2011-MZYY：05,2011-MZYY.07）
关键词
草乌
双酯型生物碱
红外光谱法
质量评价
RadixAconitikusnezoffii
Diesteralkaloids
InfTaredspectroscopy
Quality evaluation
