摘要
目的 :探讨足月妊娠应用米索前列醇引产的安全性和效果。方法 :选择正常单胎头位足月妊娠具有引产指征 ,而无禁忌症 10 0例 ,随机分成两组 ,米索组用米索前列醇 5 0μg放置阴道后穹窿 ,每 3h服 1次 ,共 3次 ,缩宫素组用缩宫素 2 .5 IU加入 5 %葡萄糖 5 0 0 ml内。结果 :米索组引产的有效率为 95 .46 % ,缩宫素组为 80 .85 % ,P<0 .0 5 ,有显著差异 ,低宫颈评分引产成功率 ,米索组 84.0 9% ,缩宫素组 48.94% ,P<0 .0 5 ,有显著差异 ,总产程时间米索组短于缩宫素组 ,二组分娩方式、产后出血、以及新生儿情况比较无显著差异。结论 :米索前列醇应用于足月妊娠引产既能促宫颈成熟 ,又能于短时间内发动规律宫缩 ,两者同步化 ,是一种使用方便、安全有效、价格便宜的引产方法 。
Objective:To study the efficacy and safety misoprostol for labor induction in term pregnancy.Methods:100 normal term pregnant women with single pregnant,vertex present were selected in study group,all case in study group rad indication for labor induction,without contra indication of labor induction.The 100 women were randomly assigned misoprostol group(group miso) and oxytocin group(group oxy).In group miso:50 μg misoprostol was placed in the posterior vaginal fornix every 3 hours up to 3 times.In group oxy:2.5 IU oxytocin added into 500 ml 5% GS intra venously guttae for labor induction.Results:The sucesess rate of induction labor was 95.46%,80.85% in group miso and group oxy respectively.With singnificant difference( P <0.05).The sucesess rate of induction labor of lower Bishop Scores was 84.09% and 48.95% in group miso and group oxy respectiveldy.With singnificant difference( P <0.05).The duration of labor in group miso was shorter than that in group oxy.No singnificant difference was found among labor patterns,outcome of newborn,postpartum hemorrhage( P >0.05).Conclusions:Misoprostol may ripen the cervix and can trigger order uterine contraction at the same time.It is an efficient,safe and convenient agent for labor induction in term pregnancy.But the use of misoprostol for labor induction require careful monitoring.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2000年第3期139-141,共3页
Journal of Practical Obstetrics and Gynecology
