摘要
microRNA(miRNA)是一类非编码小RNA分子,主要通过结合于靶基因的3'非翻译区导致其靶mRNA的降解或阻碍其靶mRNA的翻译。miRNA在冠心病的发生进展中发挥了重要的调控功能,极有可能成为冠心病新的生物标记物和治疗靶点。辨证论治是中医治疗冠心病的优势和特色所在,实现对冠心病中医证候动态时空定性和定量的把握是提高冠心病临床疗效的关键环节。miRNA表达的特异性和时序性与证候的动态时空特征极其相似,且miRNA与冠心病密切相关。将miRNA引入冠心病中医证候的研究,借助miRNA芯片和生物信息学技术,建立和证候相关的miRNA调控网络,为从转录后水平阐明冠心病中医证候的实质提供了新的视角。
microRNA （miRNA） is single-stranded small non-coding RNA, which binds to the 3′untranslated region of the target mRNAs and negatively regulates the expression of the target mRNAs by translational inhibition or miRNA cleavage. miRNA plays an important role in regulating the occurrence and progression of coronary artery disease （CAD）, and could be potential biomarkers and treatment targets of CAD. The syndrome typing is the superiority and feature for treating CAD by Chinese medicine（CM）. To master the space-time qualitation and quantitation is the key step in improving the clinical efficacy of treating CAD. The specificity and sequence of miRNA are very similar to the dynamic space-time features of syndromes. Besides, miRNA is closely correlated with CAD. Therefore, by using miRNA microarray and bioinformatics to build CM syndrome correlated miRNA regulating networks, miRNA can be introduced to study the CM syndromes of CAD, thus providing a new angle to elucidate the essence of CM syndrome of CAD at the post-transcriptional level.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2012年第11期1562-1565,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金项目(No.81173116)
关键词
MICRORNA
冠心病
中医证候
microRNA
coronary artery disease
Chinese medical syndrome
