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T细胞表达MHC Ⅱ类分子在器官移植免疫耐受中的意义 被引量：4

The role of MHC Ⅱ ＋ T lymphocytes in immune tolerance in- duction
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摘要 传统认为抗原提呈细胞表达MHCⅡ类抗原。但是，有研究发现部分T细胞也可以在特定条件下表达MHCⅡ类抗原，其发生机理及生物学效应受到众多学者的关注。本文就表达MHCⅡ类抗原的T细胞亚群的产生、作用机制及其与免疫耐受的关系等方面的研究进行综述，旨在为临床诱导器官移植免疫耐受提供参考。 Traditionally, antigen presenting cells were shown to express MHC Ⅱ antigens. However, some r searchers have demonstrated that a subset of T lymphocytes could express MHC Ⅱ antigens in some situation. Its regula- tory mechanism and biological effects remains challenging to researchers. This review provides an overview of the results of these MHC Ⅱ ＋ T lymphocytes regarding to the generation, mechanisms, and the role in immune tolerance induction, aim to provide some insights in clinical immune toler- ance induction.
作者 王海洋 朱继巧 李先亮 陈大志
机构地区 首都医科大学附属北京朝阳医院肝胆胰脾外科
出处 《中华肝胆外科杂志》 CAS CSCD 北大核心 2012年第11期880-883,共4页 Chinese Journal of Hepatobiliary Surgery
基金 国家自然基金面上项目（81273210） 国家自然科学基金委主任基金（81041110） 北京市海外留学人才择优资助优秀项目 人力资源和社会保障部留学人员科技活动择优资助启动类 北京市自然基金面上项目（7122066 7122071） 北京朝阳医院启动基金
关键词 MHCⅡ类抗原 T细胞 器官移植 免疫耐受 MHC Ⅱ antigen T-lymphocytes Organ transplantation Immune tolerance
分类号 R392 [医药卫生—免疫学]
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中华肝胆外科杂志
2012年 第11期

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