摘要
目的探讨血清胱抑素C水平变化与妊娠期高血压疾病的关系，评估胱抑素C对妊娠期高血压疾病诊断价值。方法随机抽取2011年7月-2012年1月湖北省妇幼保健院住院分娩孕产妇为研究对象。收集妊娠期高血压疾病253例，同时选择无妊娠合并症与并发症健康孕妇250例作为对照组，检测孕妇血清胱抑素C（CysC）、＆微球蛋白（β2-MG）、尿素氮（BUN）、尿酸（UA）及C-反应蛋白（cRP）水平进行比较。结果妊娠期高血压疾病组各项指标水平均高于对照组，且差异有统计学意义（P〈0．05）。妊娠期高血压疾病组血清CysC与β2-MG、UA水平呈正相关，与β2-MG相关性最强（r=0．586，P〈0．05）。CysC、β2-MG、UA与BUN的ROC曲线下面积（AUC）分别为0．862（95％CI为0．734-0．923）、0．763（95％CI为0．652-0．822）、0．742（95％CI为0．527-0．718）和0．704（95％CI为0．421-0．615），差异有统计学意义（P〈0．01）。结论胱抑素c在评价妊娠期高血压疾病早期肾损害中起重要作用。
Objective To explore the relationship between serum cystatin C level and hypertensive disorder complicating pregnancy （HI）CP）, and to evaluate the diagnostic value of cystatin C in HDCP. Methods Two hundred and fifty- three ly- ing- in women with HDCP hospitalized in Hubei Provincial Maternal and Child Health Hospital from July 2011 to January 2012 were randomly selected as research objects. Meanwhile, 250 healthy lying- in women were selected as the controls. The levels of Cys - C, β2- MG, BUN, UA, and CRP were detected and compared between the two groups. Results The levels of Cys - C, β2- MG, BUN, UA, and CRP in HDCP group were all higher than those of control group, and the difference was statistical- ly significant （P 〈 0.05）. The level of serum CysC in HI）CP group was positively correlated with β2- MG and UA levels, more- over, it was the mostly associated with β2- MG level （ r = 0. 586, P 〈 0.05）. The areas under ROC curves of Cys - C, β2- MG, BUN, UA, and CRP were 0. 862 （95 % CI = 0. 734- 0. 923）, 0. 763 （95 % CI = 0. 652- 0. 822）, 0. 742 （ 95 % CI = 0. 527 0. 718）, and 0. 704 （95 % CI = 0. 421 - 0. 615 ）, respectively, and the difference was statistically significant （ P 〈 0.01 ）. Conclusion Serum CysC plays an important role in the evaluation of early renal damage of HI）CP.
出处
《实用预防医学》
CAS
2012年第11期1673-1674,共2页
Practical Preventive Medicine
