摘要
充足的能量及营养供应是癌细胞生长、浸润及转移的基础,能量代谢异常是癌细胞最显著的特征之一。癌细胞存在广泛的能量代谢异常包括蛋白质和脂肪代谢异常,而有氧糖酵解是癌细胞能量代谢的主要方式。近年来,以糖酵解、氨基酸及脂肪代谢关键酶或载体作为靶标对一些肿瘤进行分子靶向治疗取得了一些重要成果,具有广阔的临床应用前景。
Abundant energy and nutrition supply is essential for growth, filtration and metastasis of tumor cells. Tumor cells are known for their altered energy metabolism characteristics. Aerobic glycolysis, known as ＂Warburg effect＂,is the most recognized metabolic abnormality of tumor cells. In addition,protein and lipid metabolism is also reported abnormal in tumor cells. The abnormality of tumor cells provided novel possibilities to interfere tumor cell growth. Recently, targeting key metabolic enzymes in cancer treatment has made significant progresses and is showing a promising clinical prospect.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2012年第6期676-679,共4页
Fudan University Journal of Medical Sciences
基金
中央高校基本科研业务费专项资助项目(lzujbky-2012-224)
兰州大学第一医院院内基金项目(ldyynjx 201112)~~
关键词
恶性肿瘤
糖酵解
能量代谢
malignant tumor
aerobic glycolysis
energy metabolism
