摘要
目的 :用磷霉素氨丁三醇与环丙沙星随机对照治疗急性细菌性泌尿道感染 ,对前者进行安全性及有效性评价。方法 :磷霉素氨丁三醇 3g,QD ,疗程 5天 ,环丙沙星 2 5 0mgBid ,疗程 5天。结果 :共完成 41例 (试验组 2 1例 ,对照组 2 0例 ) ,病种包括急性膀胱炎、急性尿道炎、急性肾盂肾炎、慢性肾盂肾炎急发、复杂尿路感染。试验组与对照组对不同感染病种患者的有效率分别为 95 2 4%与 90 0 0 % ;与两组不同细菌感染者的有效率相似 ,无显著性差异 (P >0 0 5 ) ,两组细菌清除率分别为 10 0 %与 94 44 % ,不良反应发生率分别为 4 76 %与5 0 0 % ,差异无显著性 (P >0 0 5 )。 36株细菌对磷霉素氨丁三醇与环丙沙星敏感率为 77 77%与 75 0 0 %。结论 :磷霉素氨丁三醇抗菌谱广 ,抗菌活性强 ,为一治疗急性细菌性泌尿道感染安全有效的口服药物。
Objective:The efficacy and safty of fosfomycin trometamal versus ciprofloxacin were evaluated through randomized controlled clinical trials on patients with acute urological tract bacterial infections.Method:Twenty-one patients enrolled in trial group and received fosfomycin trometamal 3g QD for 5days;20 in control groups received I ciprofloxacin 250mg Bid for 5 days.Results:The efficacy rate in each group were 95 24% and 90 00%,bacterial eradication rate were 100% and 94 44%,92 31%,adverse events rate were 4 76% and 5 00% respectively.There were no significant differences between the relavant rates ( P >0 05).The sensititvity rate of bacterial isolates to fosfomycin trometamal and ciprofloxacin were 77 77% and 75 00%,mildly higher than that of ciprofloxacin.Conclusion:The results suggested that fosfomycin trometamal with wide antibacterial spectrum,satisfactory activity,is an effective and safe antibiotics in treatment of mild to moderate acute ,urological tract bacterial infections.[WT5”HZ]
出处
《华西医学》
CAS
2000年第2期172-175,共4页
West China Medical Journal
关键词
磷霉素氨丁三醇
环丙沙星
随机对照
泌尿道感染
Fosfomycin trometamal
Ciprofloxacin
Randomized-controlled
Clinical trial
Urological tract infection.
