摘要
目的比较硫酸阿托品、盐酸环喷托酯对青少年远视散瞳验光效果影响差异，为青少年散瞳验光药物的合理选择提供依据。方法将90例（180眼）远视青少年先后给予1％盐酸环喷托酯滴眼液和1％硫酸阿托品眼用凝胶进行散瞳验光，处理后分别采用人工检影的方法得出验光结果，记录球镜度数、柱镜度数、散光轴向，并采用日本TOPCON全功能电脑自动综合验光仪进行推近法测量残余调节量，测量瞳孔直径，观察两种药物的不良反应。结果盐酸环喷托酯和硫酸阿托品球镜度数符合率为84．44％（152／180），柱镜度数符合率为92．78％（167／180），散光轴向符合率为92．78％（167／180）；盐酸环喷托酯球镜度数低于硫酸阿托品，差异有统计学意义（P〈0．01），盐酸环喷托酯和硫酸阿托品柱镜度数及散光轴向比较差异无统计学意义（P〉0．05）；盐酸环喷托酯散瞳后瞳孔直径、残余调节量与硫酸阿托品比较差异无统计学意义（P〉0．05）；盐酸环喷托酯不良反应发生率为3．33％（3／90），硫酸阿托品为13．33％（12／90），盐酸环喷托酯不良反应发生率明显低于硫酸阿托品，差异有统计学意义（P〈0．05）。结论盐酸环喷托酯应用儿童远视散瞳验光具有强效、快速且安全的特点，具有较好麻痹睫状肌作用，麻痹效果持续时间长，效果与硫酸阿托品相当，且恢复时间短，安全性更好，是青少年远视散瞳验光理想的睫状肌麻痹药。
Objective To compare the effect of atropine sulphate and cyclopentolate hydrochloride in the treatment of youth hyperopia cycloplegic refraction, and provide the basis for a reasonable choice of the youth cycloplegic refraction drugs. Methods Ninety hyperopia children met inclusion criteria with refractive errors （180 eyes） were subjected to cycloplegic refratometry by 1% cyclopentolate hydrochloride followed with 1% atropine sulphate eye used gel. The refractive results, pupil size,residual adjustment amount and systemic side reactions were measured and compared by TOPCON. Results The coincidence rate of spherical lens degrees ,cylinder lens degrees and axis of astigmatism degrees respectively was 84.44% （152/180）,92.78% （167/180） and 92.78% （167/180） between atropine sulphate and cyclopentolate hydrochloride. The spherical lens degrees of cyclopentolate hydrochloride was lower than atropine sulphate, the difference was statistically significant （P 〈 0.01 ）, the cylinder lens degrees and axis of astigmatism degrees had no significant difference between two drugs （P 〉 0.05 ）. The pupil size and residual adjustment amount of cyclopentolate hydrochloride had no significant difference with atropine sulphate （P 〉 0.05 ）. The incidence of adverse reactions of cyclopentolate hydrochloride was 3.33% （3/90）, atropine sulphate was 13.33% （12/90）, the cyclopentolate hydrochloride was significantly lower than atropine sulphate （P 〈 0.05 ）. Conclusion The cyclopentolate hydrochloride has powerful, fast and secure feature in the treatment of youth hyperopia cycloplegic refraction, has good ciliary muscle paralysis effect, has longer paralysis time, as effective as the atropine sulphate, and has a shorter recovery time and better security, is ideal cycloplegic drugs for youth hyperopia cycloplegic refraction.
出处
《中国医师进修杂志》
2012年第33期15-17,共3页
Chinese Journal of Postgraduates of Medicine
关键词
阿托品
环喷托酯
散瞳药
Atropine
Cyclopentolate
Mydriatics
