摘要
目的研究血浆N末端B型利钠肽原（NT—proBNP）与超敏C反应蛋白（hs—CRP）联合检测对冠脉病变的临床评估价值。方法选取我院148例冠脉病变患者，按照确诊分为：AMI组，诊断为急性心肌梗死，共51例；UAP组，诊断为不稳定型心绞痛，共48例；NSTEMI组，诊断为非ST段抬高心肌梗死，共49例。以正常体检患者50名为对照组。比较各组静脉血NT—proBNP、hs—CRP、肌酸肌酶同工酶（CK—MB）及肌钙蛋白I（cTnI）的差异。随访3个月，观察主要心脏事件（MACE）发生率与上述指标的相关性。结果AMI组的NT—proBNP[（162．3±27．6）mg／L]和hs—CRP[（17．2±3．5）mg／L]值最大，对照组最小，分别为NT—proBNP（44．1±6．8）mg／L，hs—CRP（3．9±0．8）mg／L（P〈0．05），UAP组的NT—proBNP和hs—CRP与NSTEMI组比较[NT—proBNP[（85．5±11．8）mg／L比（101．7±32．2）mg／L，hs—CRP（8．4±1．5）mg／L比（14．3±2．3）mg／L]，差异无统计学意义（P〉0．05）。NT—proBNP与hs—CRP浓度与3个月内的MACE有相关性，P值分别为0．023和0．036。结论NT—proBNP与hs—CRP联合检测能有效评估冠脉病变情况，有利于临床诊断。
Objective To analyze the prognostic value of NT-proBNP and hs-CRP on assessment of coronary heart disease （CHD）. Methods The data of 148 patients with CHD were collected to retrospectively study. All patients were divided into three groups, AMI group （diagnosis to AMI, 51 cases）, UAP group （diagno-sis to UAP, 48 cases）, NSTEMI group （diagnosis to NSTEMI, 49 cases）. And 50 cases, which were normal physical examination, were chosen to control group. The value of NT-proBNP, hs-CRP, CK-MB and eTnI were compared among four groups. The relationship between the incidence of major adverse cardiovascular events （MACE） and the above indexes were analyzed after 3 months following-up. Results Among four groups, the val-ues of NT-proBNP[ （162.3＋27.6）mg/L] and hs-CRP[ （17.2±3.5）mg/L] in AMI group were highest, and in con-trol group were lowest（P〈0.05）, but in UAP group（NT-proBNP[ （85.5±ll.8）mg/L] and hs-CRP[（8.4±1.5）mg/L]） and NSTEMI group （NT-proBNP [ （ 101.7±32.2）mg/L] and hs-CRP[ （14.3±12.3）mg/L]） were no different（P〉 0.05 ）. There was correlation between the values of NT-proBNP and hs-CRP and the incidence of MACE after 3 months following-up by Logistic regression analysis （P value were 0.023 and 0.036）. Conclusion The prognostic value of NT-proBNP and hs-CRP on assessment of CHD is perfect.
出处
《中国心血管病研究》
CAS
2012年第11期821-823,共3页
Chinese Journal of Cardiovascular Research
