摘要
目的探讨阿维A治疗寻常性银屑病疗效与药物遗传学的相关性。方法运用PCR、电泳、测序等方法检测寻常性银屑病患者的基因单核苷酸多态性,同时观察阿维A治疗寻常性银屑病的临床疗效。结果 100例寻常性银屑病患者中rs833061C/C型10例(10%),rs833061T/T型46例(46%),rs833061C/T型44例(44%),rs2010963G/G型51例(51%),rs2010963C/G型33例(33%),rs2010963C/C型16例(16%)。rs833061C/T型患者采用阿维A治疗的有效率为90.9%,高于其他各型,差异有统计学意义(P<0.05)。其他各型之间的治愈率和有效率相比差异无统计学意义(P>0.05)。结论阿维A治疗寻常性银屑病,其基因型为rs833061C/T的患者治疗效果好。
Objective To study the correlation between therapeutic efficacy of acitretin treatment of psoriasis vulgaris and pharmacogenomics. Methods Gene single nucleotide polymorphism were detected by PCR, electrophoresis, gene sequencing means. Meanwhile, clinical curative effect of acitretin treatment of psoriasis vulgaris was evaluated. Results Among the 100 patients with psoriasis vulgaris, 10 cases of genes is rs833061C/C（10%）, 46 is rs833061T/T （46%）, 44 is rs833061C/T（44%）; 51 is rs2010963G/G（51%）, 33 is rs2010963C/G （33%）, 16 is rs2010963C/C（16%）. The efficiency （90.9%） in patients with genotype of rs833061C/T was significantly higher than other groups（P〈0.05）. Among other groups, the effective rate difference was not statistically significant （P〉0.05）. Conclusion Treatment of psoriasis vulgaris with acitretin, patients with genotype of rs833061C/T were most effective,
出处
《实用皮肤病学杂志》
2012年第6期327-330,共4页
Journal of Practical Dermatology
基金
上海市卫生局科研基金(2009212)
上海市卫生局中医药科研基金(2010L074A)
