摘要
目前，随着心血管疾病日益增多，国外有少量研究者开始分析心定复极化时程变异（Repolarizationdurationvariability，RDV），某些心脏疾病会在心室复极化时程变异上会有所表现。我们用乌拉坦麻醉大白鼠，研究用阿托品阻断迷走神经前后，RDV的变化规律。通过正常人体位变化来改变人体自主神经系统的平衡状态，以研究心室复极化时程与自主神经系统的关系。发现大白鼠的HRV和RDV的谱分析的峰值频率都受到吸呼频率的调制。阻断迷走神经后，HRV和RDV的HFnu都显著减小，LF／HF都显著增加。人体倾斜时，HRV和RDV的LF／HF显著高于平躺时，这与体位变化时自主神经系统的变化是一致的。从动物实验和人体实验结果看到心室复极化时程受到自主神经系统的影响。随着心室复极化时程变异研究的不断深入，将使评价心脏疾病和功能的无创性方法更趋完善，必将在临床上发挥更大的作用。
Cardiovascular disease is a growing problem recently. There has been a few attention in the study of ventricular repolarization duration variability. RDV is associated with some cardiac diseases. We studied vagal blockade effects on RDV in urethane-anesthetized rats. To study the relation between ventricular repolarization duration and autonomic nervous system in subjects, we changed the balance of autonomic nervous system by body posture. The HRV and RDV spectral analysis showed that HF peak was modulated by the frequency of controlled respiration. We also found a significant decrease in HFnu and increase in LF/HF in HRV and RDV during vagal blockade. There is a significant increase of LF/HF of subjects in HRV and RDV from supine to tilt, which is consistent with the state of autonomic nervous system. The result of our study is that the ventricular repolarization duration is dependent on the autonomic nervous system. The RDV analysis will be more helpful in the clinic. This approach will provide a more useful noninvasive evaluation of cardiac disease and function.
出处
《生物医学工程学杂志》
CAS
CSCD
北大核心
2000年第2期192-195,共4页
Journal of Biomedical Engineering
基金
上海市教委科学技术基金!95B16
关键词
心室复极化时程变异
自主神经系统
大白鼠
Ventricular repolarization duration variability Autonomic nervous system Rat experiment Atropine Body posture
