摘要
目的通过对A型肉毒毒素肌内注射后小同时间段肌肉的改变进行观察，了解肉毒毒素对肌肉的改变过程，并为化学去神经肌肉游离移植提供理论依据。方法对16只活体兔桡侧腕伸肌进行肉毒毒素注射，分为4组（即1、2、3、4周组）．每组4个肌肉，躯体对侧作为对比。分别在注射后1～4周进行大体观察，以及组织学和电镜观察。结果药物注射后1周，肌内酶、糖原和线粒体都开始减少，体积的减少在3周左右明显，4周后肌酶的减少更加明显，并且内部区域有坏死灶，但体积较前有所恢复。结论A型肉毒毒素肌内注射后可以减缓肌肉代谢和缩小肌肉体积，其中以第3周最为明显。可以为化学去神经肌肉游离移植的时间选择提供参考。
Objective To study the changes of muscle being injected with botulinum toxin A in different period of time, helping for chemically denervated nmscle transplantation. Methods Sixteen rabbits were divided into 4 groups. The extensor carpi radialis muscle in one side was chosen for experimental group with the opposite muscle for control group. Morphological changes, histologi cal changes and electron microscopic changes of muscle being injected with botulinmn toxin A were observed from the first week to the fouth week. Results The quantity of glycogen and mitochondria in the muscles reduced in the first week. But it was obvious in the third week. We also found some nec rodc areas in the fouth week with the muscles restoring. Conclusions The effect of metabolism slowing down and the volume of muscle reducing after hotulinum toxin A injection is obvious in third weeks. It could help us choose the best time of chemically denervated muscle transplantation.
出处
《中华医学美学美容杂志》
2012年第6期444-446,共3页
Chinese Journal of Medical Aesthetics and Cosmetology
关键词
A型肉毒毒素
肌肉
代谢
Botulinum toxin A
Muscle
Metabolism
