摘要
目的探讨超选择子宫动脉灌注化疗对局部晚期宫颈癌的作用。方法选择局部晚期宫颈癌20例,行超选择子宫动脉灌注化疗,动态观察化疗后21d宫颈肿瘤局部、组织病理学及血清SCC-Ag变化。结果临床有效率为70%,可手术率为67%;病理变化:化疗后早期(第1w)癌细胞以点片状坏死为主,晚期(第2～3w)出现大片坏死,甚至部分病理反应完全缓解,炎性细胞、淋巴细胞浸润及纤维组织增生明显;化疗前、后血清SCC-Ag水平表达差异有统计学意义(P<0.05)。结论超选择子宫动脉灌注化疗缩小宫颈肿瘤局部病灶,提高可手术率,癌组织病理变化同化疗作用时间密切相关,结局为肿瘤细胞坏死增加,肿瘤负荷水平降低,达到新辅助化疗治疗目的。
Objective To superselective uterine artery infusion chemotherapy through the dynamic observa tion of cervical tumor local, organizational changes in the pathology and serum SCC-Ag, and to investigate the role of superselective uterine artery infusion chemotherapy for locally advanced cervical cancer. Methods Twenty cases of locally advanced cervical cancer, superselective uterine artery infusion chemothera py, dynamic observation after chemotherapy in 21 days of cervical cancer local histopathology and serum SCC-Ag changes. Results After chemotherapy, the clinical efficiency was 70 %, the reoperation rate was 67%; the pathological changes were：at early （1 week） time, there was the main cancer focus necrosis, and late （2-3 weeks）, there were large areas of necrosis, even part of the pathological completely relieved,inflammatory cell infiltration of lymphocytes and fibrous tissue proliferated obviously; the SCC-Ag level of expressions significantly different before and after chemotherapy. Conclusion Superselective uterine arterial infusion chemotherapy can reduce the partial lesions of the cervical tumor, increase the resection rate, pathological change of cancerous tissue is closely related to the role of time with chemotherapy, the outcome for the tumor necrosis increased to reduce the level of tumor burden, to achieve the purpose of neoad juvant chemotherapy.
出处
《新疆医科大学学报》
CAS
2012年第12期1632-1637,共6页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区自然科学基金(2010211A31)
乌鲁木齐人才工程项目基金(P07131003)
