摘要
目的探讨维生素A棕榈酸酯眼用凝胶预防及治疗近视患者LASIK术后干眼症的疗效。方法对466例(932只眼)拟行LASIK治疗的近视患者做术前泪膜相关筛查,通过术前筛查排除严重的干眼症患者,对轻、中度干眼患者通过围手术期维生素A棕榈酸酯眼用凝胶点眼治疗,非干眼患者术后应用维生素A棕榈酸酯眼用凝胶点眼预防干眼发生。观察术后1周及1、3、6个月的干眼症发生率。结果术前诊断为轻、中度干眼症并术前用药的155只眼于术后7 d及1、3、6个月做泪膜相关检查并诊断为干眼症的眼数分别为69只眼(44.6%)、52只眼(33.4%)、26只眼(16.6%)、7只眼(4.6%)。术前筛查已排除干眼症的761只眼于术后开始用药,术后7 d及1、3、6个月检查符合干眼症诊断的分别为244只眼(32.1%)、145只眼(19.0%)、64只眼(8.4%)、12只眼(1.6%)。结论采取术前筛查和围手术期药物干预是预防和治疗LASIK术后干眼症的有效措施;维生素A棕榈酸酯眼用凝胶可以有效预防及治疗LASIK术后干眼症。
Objective To study the efficacy of vitamin A palmitate eye gel on preventing and treating dry eye after laser in situ keratomileusis（LASIK）in myopia.Methods Via tear film related screening performed in 466（932 eyes）myopic patients before LASIK for dry eye,some dry eye patients were found with the exclusion from LASIK for severe.The light or moderate patients were given vitamin A palmitate eye gel during peri-operation period.For the non dry eye patients,meanwhile,precautions were taken against dry eye with vitamin A palmitate eye gel postoperatively.The incidence of dry eye was observed at 1 week,1,3 and 6 months postoperatively.Results The incidences of dry eye in 155 eyes with preoperative dry eye diagnosis were 44.6%（69 eyes）at 1st week,33.4%（52 eyes）at 1st month,16.6%（26 eyes）at 3rd month and 4.6%（7 eyes）at 6th month postoperatively.For 761 eyes non-dry-eye preoperatively,the incidences of dry eye were 32.1%（244 eyes）at 1st week,19.0%（145 eyes）at 1st month,8.4%（64 eyes）at 3rd month and 1.6%（12 eyes）at 6th month after LASIK.Conclusion Dry eye can be prevented and treated effectively by preoperative screening and drug intervention;vitamin A palmitate eye gel is effective in the prevention and treatment for dry eye after LASIK.
出处
《实用药物与临床》
CAS
2012年第12期810-812,共3页
Practical Pharmacy and Clinical Remedies
