摘要
目的观察手足口病(HFMD)患儿外周血共刺激分子CD80、CD86的变化。方法根据病情将55例手足口病患儿分为普通组30例、重症重型组25例。以20例健康儿童作为对照,采用流式细胞术,检测75例小儿外周抗凝全血的CD80细胞、CD86细胞的相对计数。结果手足口病患儿外周血CD80细胞的百分率(F=53.032,P=0.000)和CD86细胞的百分率(25.188,P=0.000)在各组间数值比较,差异有统计学意义。对照组与普通组和重症重型组数值比较差异均有统计学意义(P均<0.001),普通组与重症重型组数值比较差异无统计学意义(P>0.05)。结论 CD80和CD86共刺激分子参与了HFMD的发病。
Objective To observe the changes of CDS0 and CD86 costimulatory molecules in eripheral blood of Chlidren with hand foot and mouth disease and their clinical significance. Methods 55 cases of children with HFMD were divided into mild group and severe group under the condition. 55 cases with HFMD and 20 healthy children as control group were enrolled in the study. The percentage of the CDS0 and CD86 costimulatory molecules in anticoagulative whole blood of patients from the three groups were determined by fluorescence flow cytometry. Results There were significant differences in the percentage of CD80 （F = 53. 032, P = 0. 000） and CD86 （25. 188, P = 0. 000） costimulatory molecules among the three groups. There was significant difference between control group and mild group（ P 〈 0.01 ）. There was significant difference between control group and severe group （ P 〈 0.01 ）. There was no significant difference between mild group and severe group （ P 〉 0.05 ）. Conclusion The CD80 and CD86 costimulatory molecules maybe participated in the pathogenesis of the HFMD.
出处
《中华全科医学》
2013年第1期129-129,132,共2页
Chinese Journal of General Practice
