摘要
目的观察补肾清肺法治疗哮喘急性发作期(热哮证)的临床疗效。方法将180例哮喘急性发作期(热哮证)患者随机分为治疗组和对照组各90例。治疗组口服清肺渗湿汤合六味地黄汤,对照组口服清肺渗湿汤。两组均每日1剂,连续服药9天后观察临床疗效。并观察两组治疗前后症状、体征、肺通气功能检查[包括最大呼气峰流速(PEF)、一秒钟用力呼气容积/用力肺活量(FEV1.0/FVC)、用力呼气中期流量(MMEF75/25)]、嗜酸性粒细胞(EOS)绝对值计数、EOS复常率及用药后具体生效时间。结果治疗组控显率86.67%、对照组75.56%,治疗组优于对照组(P<0.05)。两组治疗后PEF、FEV1.0/FVC、MMEF75/25均较治疗前明显改善(P<0.05),治疗组治疗后改善程度优于对照组(P<0.05)。两组治疗后EOS绝对值计数均较治疗前明显降低(P<0.05),治疗组治疗后下降程度优于对照组(P<0.05)。治疗组治疗后EOS复常率为89.87%,高于对照组的77.92%(P<0.05)。治疗组用药生效时间短于对照组(P<0.05)。结论补肾清肺法治疗哮喘急性发作期(热哮证)较传统清宣肺气治疗可明显提高疗效。
Objective To observe the therapeutic effect of kidney-supplementing lung-clearing therapy on asthma of acute attack with heat sydnrome.Methods Totally 180 heat asthma patients with acute attack were randomized into treatment group and control group,with 90 in each.The control group was given Lung-Clearing Dampness-Percolating Decoction.The treatment group was added Six-Ingredient Rehmannia Decoction orally.One dose of decoction was given daily and administrated for 9 days as one treatment course.The symptoms,signs,peak expiratory flow rate（PEF）,forced expiratory volume in 1 second to forced vital capacity（FEV1.0/FVC）,maximum mid-expiratory flow （MMEF75/25）,absolute eosinophils（EOS）count, EOS normalization rates and effective time after medication were observe before and after treatment.Results The rate of relieving asthma in the treatment group and control group was 86.67% and 75.56% respectively,with significant difference between groups（P0.05）.The PEF,FEV1.0/FVC and MMEF75/25 were significantly improved in both groups（P0.05）, especially in the treatment group（P0.05）.The absolute EOS content was significantly decreased in both groups（P0.05）, especially in the treatment group （P0.05）.The EOS normalization rate in the treatment group was 89.87%,which was higher than 77.92% in the control group（P0.05）.The effective time after medication in the treatment group was shorter than that in the control group（P0.05）.Conclusion The kidney-supplementing lung-clearing therapy is more effective for heat asthma with acute attack as compared with traditional lung-clearing therapy.
出处
《中医杂志》
CSCD
北大核心
2013年第1期48-50,共3页
Journal of Traditional Chinese Medicine
基金
山东省中医药科学技术发展计划(2002-162)
关键词
哮喘
热哮证
补肾清肺法
清肺渗湿汤
六味地黄汤
asthma
heat asthma
kidney-supplementing lung-clearing therapy
Lung-Clearing Dampness-Percolating Decoction
Six-Ingredient Rehmannia Decoction
