摘要
目的研究呼出气一氧化氮浓度(fractional nitric oxide concentration in exhaled breath,FeNO)测定技术在辅助评价儿童哮喘控制水平方面的应用价值。方法将226例哮喘患儿分为哮喘控制组(n=86)、部分控制组(n=63)和未控制组(n=77),90例健康儿童为对照组。采用瑞典尼尔斯(NIOX)呼出一氧化氮测定仪测定哮喘患儿和健康对照儿童FeNO浓度。结果对照组儿童FeNO浓度为14±6 ppb,控制组为29±26 ppb,部分控制组为32±30 ppb,未控制组为40±32 ppb,3组哮喘患儿的FeNO浓度均高于对照组(P<0.05);哮喘未控制组患儿FeNO浓度高于控制组(P<0.05);哮喘部分控制组FeNO浓度与未控制和控制组之间差异无统计学意义。结论哮喘患儿FeNO水平显著高于健康儿童,且与哮喘控制程度相关。
Objective To investigate the value of fractional nitric oxide concentration in exhaled breath （FeNO） in assessing the level of asthma control in children. Methods A total of 226 asthmatic children were divided into controlled asthma （n = 86）, partially controlled asthma （n = 63）, and uncontrolled asthma groups （n = 77）. Ninety healthy children were enrolled as controls. FeNO was measured for both asthmatic and healthy children using the Swedish-designed NIOX system. Results The control group had an FeNO of 14±6 ppb, the controlled asthma group had an FeNO of 29 ± 26 ppb, the partially controlled asthma group had an FeNO of 32± 30 ppb, and the uncontrolled asthma group had an FeNO of 40 ±32 ppb. The three asthma groups showed significantly higher FeNO than the control group （ P 〈 0.05 ）. The uncontrolled asthma group showed significantly higher FeNO than the controlled asthma group （ P 〈 0.05 ）, but there were no significant differences in FeNO between the partially controlled and uncontrolled asthma groups and between the partially controlled and controlled asthma groups （P 〉 0. 05 ）. Conclusions Asthmatic children have significantly higher FeNO than healthy children, and FeNO is correlated with the level of asthma control.
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2013年第1期29-32,共4页
Chinese Journal of Contemporary Pediatrics
基金
北京市卫生系统高层次卫生技术人才培养计划(批准号:2011-3-053)
关键词
哮喘
控制水平
呼出气一氧化氮
儿童
Asthma
Level of asthma control
Fractional nitric oxide concentration in exhaled breath
Child
