摘要
目的研究甘草总黄酮的止痒作用,初探其可能的作用机制,为将其开发为治疗皮肤瘙痒的药物提供一定的药理学依据。方法采用右旋糖酐所致的小鼠皮肤瘙痒模型和4-氨基吡啶(4-AP)诱发的小鼠瘙痒模型,观察甘草总黄酮对两种皮肤瘙痒模型的影响。另分别在不同模型中观察其对皮肤组胺含量、皮肤毛细血管通透性、肥大细胞脱颗粒、迟发型超敏反应等的影响,综合评价甘草总黄酮的止痒作用。结果甘草总黄酮对药物所诱发的小鼠皮肤瘙痒有明显的抑制作用,可抑制4-AP所诱发的小鼠皮肤组胺释放;对抗组胺所致的小鼠皮肤毛细血管通透性的增加;对大鼠颅骨骨膜肥大细胞脱颗粒反应和2,4-二硝基氯苯(DNCB)所致的迟发型超敏反应都有显著的抑制作用。结论甘草总黄酮具有较好的止痒作用,可能与抗组胺及抑制肥大细胞脱颗粒有关。
Objective To study the antipruritic effects of flavonoids of glycyrrhiza（FG） and to investigate the primary mechanism.Methods Observed the effects of FG on the skin pruritus of mice respectively induced by Dextran and 4-aminopyridine（4-AP）.Also observed the effects of FG on skin histamine content,skin capillary permeability,mastocyte degranulation and delayed-type hypersensitivity as well to comprehensively evaluate its antipruritic effect.Results FG could inhibit the mice skin pruritus induced by Dextran and 4-AP significantly,reduce mice skin histamine releasing induced by 4-AP,obviously antagonized the increase of mice skin capillary permeability induced by histamine,effectively inhibited the rats mastocytes degranulation type hypersensitivity induced by DNCB.Conclusion FG possesses antipruritic effect,which is likely related to its anti-histamine and to its inhibitory effects on mastocytes degranulation.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2012年第12期2951-2953,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.81160416)
