摘要
目的 观察葛根素注射液对冠心病心绞痛患者的临床疗效及其对血浆内皮素— 1(ET 1)和一氧化氮 (NO)水平的影响。方法 随机选择 90例老年冠心病合并心绞痛住院患者 ,分成两组 :葛根素组 (5 0例 )和对照组 (40例 )。所有患者均采用相同的口服抗心绞痛药物治疗 ,其中葛根素组加用葛根素 6 0 0mg静脉滴注 ,每天 1次 ,连用 14天。疗程前后分别测定血浆ET 1及NO水平 ,并观察治疗前后心绞痛症状及心电图变化。结果 葛根素组临床总有效率为 90 % ,心电图总有效率为80 % ;对照组依次为 6 5 %和 6 0 % ,统计学比较两组有显著差异 (P <0 0 5 )。葛根素组血浆ET 1水平治疗后较治疗前显著下降 (P <0 0 1) ,而NO水平则明显升高 (P <0 0 1)。结论 葛根素注射液能改善心绞痛患者临床症状 ,并能降低患者ET 1水平 ,升高NO水平。
Objective To evaluate the clinical efficacy of puerarin injection and its effect on plasma endothelin 1(ET 1) and nitric oxide(NO) level in patients with angina pectoris.Methods A total of 90 patients were randomly divided into two groups:puerarin group (50 cases )and control group (40 cases).Patients of puerarin group were administered with puerarin 600mg/d,i.v.×14days.ET 1 and NO in Plasma were determined pre and post treatment,symptoms and EKG of patients were recorded at the same time.Result The total efficacy rate in symptoms was 90% and that in ECG was 80% in the pueranrin group,which were higher than those of the control group,res pectively 65% and 60%( P <0 05).The plasma ET 1 level was reduced,but NO level was increased after Puerarin treatment ( P <0 01).Conclusion Puerarin may relieve symptoms of patients with angina pectoris,reduce plasma ET 1 level and raise plasma NO level.
出处
《江苏医药》
CAS
CSCD
2000年第7期524-525,共2页
Jiangsu Medical Journal
