摘要
目的探讨3种不同浓度罗哌卡因复合诺杨硬膜外阻滞应用于剖宫产镇痛效果及最佳浓度选择。方法 1620例行剖宫产术患者随机分为3组,A组(542例)、B组(530例)、C组(548例)。所有患者均采用硬膜外阻滞,分别给予0.10%、0.15%和0.20%罗哌卡因复合0.004%诺杨行硬膜外自控镇痛(PECA)。结果 B组、C组感觉阻滞起效时间、痛觉消失时间显著短于A组(P<0.05),B组与C组比较则无显著性差异(P>0.05);A组、B组运动阻滞起效时间与时效及运动阻滞程度明显高于C组(P<0.05),而A组与B组比较无显著性差异(P>0.05);A组和B组恶心呕吐、嗜睡、皮肤瘙痒等不良反应发生率均显著低于C组(P<0.05)。结论 0.15%罗哌卡因+0.004%诺杨应用于剖宫产术硬膜外阻滞,可提供较好的麻醉镇痛效果,并可减少不良反应。
Objective To explore the clinical effect of three concentrations of ropivacaine combined with butophanol on epidural anesthesia for cesarean section, and identify the optimal concentration. Methods 1620 patients treated with cesarean section were randomly divided into three groups, Group A（n=542）, Group B （n=530） and Group C （n=548）. All the patients were performed by epidural anesthesia, and given 0. 004% butophaaol combined with 0. 10% ,0. 15%, 0.20% ropivacaine respectively. Results The onset time of sense block, pain disappeared time in Group B and Group C were significantly shorter than that of Group A （P〈0. 05）, while there was not significantly difference between B group and C group （P〉0.05）. Compared with Group A and Group B, the onset time, duration and degree of motor block in Group C was significantly longer, while there was not significantly difference between Group A and Group B （P〉0.05）. The rate of side effect including nausea and vomiting, sleepiness and itchy skin in Group A and Group B was significantly lower than that of Group C（P〈0. 05）. Conclusion The concentration of 0.15% ropivacaine＋0. 004% butophanol in epidural anesthesia for cesarean section can provide good effect of anesthesia and analgesia, and reduce the side effect.
出处
《西部医学》
2013年第1期111-113,共3页
Medical Journal of West China
关键词
罗派卡因
浓度
诺杨
剖宫产
硬膜外阻滞
Ropivacaine
Butophanol
Concentration
Cesarean section
Epidural anesthesia
