摘要
应激反应是所有生物对紧张性事件的适应性反应 ,对生物的存活具有十分重要的意义。应激反应的主要特征是下丘脑 垂体 肾上腺皮质 (HPA)轴激活。HPA轴激活的中枢控制十分复杂。海马参与整合感知的信息、解释环境信息的意义及定调行为反应和神经内分泌反应。杏仁核是应激性行为反应以及自主神经和神经内分泌反应的执行部位。下丘脑室旁核则有直接激活HPA轴的作用。负反馈机制、下丘脑局部回路和细胞因子也可能参与了调节HPA轴活动。
Stress reaction is an adaptive response of all living organism to stressful events and essential for their survival. The main feature of stress reaction is activation of the hypothalamic pituitary adrenocortical (HPA) axis, central control of which is very complex. The hippocampus is involved in integration of sensory information, interpretation of environmental information, and execution of appropriate behavioral and neuroendocrine responses. The amygdala is an executor of stress behavioral, autonomic and neuroendocrine responses. The paraventricular nucleus (PVN) is responsible for initiating HPA axis stress reaction. The negative feedback regulation of stress hormones, local hypothalamic circuits and cytokines probably are involved in regulation of HPA activation.
出处
《生理科学进展》
CAS
CSCD
北大核心
2000年第3期222-226,共5页
Progress in Physiological Sciences
关键词
下丘脑-垂体-肾上腺轴
应激反应
中枢控制
Stress
Hypothalamic pituitary adrenocortical (HPA) axis
Limbic system
