摘要
目的比较单纯放疗、放化疗治疗宫颈癌的疗效以及两种方法的毒副反应。方法收集了2006年8月至2009年6月在我院收治的宫颈癌患者95例,随机分为单纯放疗组46例,放化疗组49例。比较单纯放疗组与放化疗组患者的近期疗效、1年、3年生存率和不良反应。结果全组随访时间为36个月,放化疗组与单纯放疗组近期有效率分别为95.90%和93.47%,差异无统计学意义(P>0.05)。放化疗组与单纯放疗组的1、3年生存率分别为87.8%、79.5%和78.3%、58.7%,其中3年生存率有统计学差异(2=4.855,P=0.027)。Ⅲ～Ⅳ度急性毒副反应放化疗组较单纯放疗组重(P<0.05),迟发性毒副反应两组差异无统计学意义(P>0.05)。结论①与单纯放疗相比,放化疗可明显提高ⅡB～ⅢB期宫颈癌患者的3年生存率,在迟发性毒副反应方面两种化疗方案差异无统计学意义。②紫杉醇联合顺铂方案治疗中晚期宫颈癌远期效果明显,且患者可以耐受,有很好的临床应用前景。
Objective To compare the therapeutic efficacy and toxicity of radiotherapy and chemoradio- therapy for cervical cancer. Methods Ninety - five cervical cancer cases from August, 2006 to March, 2009 in the Affiliated Hospital of Zunyi Medical College were randomly divided into the radiotherapy group （46 cases） and chemoradiotherapy group （49 cases）. The short -term therapeutic efficacy, 1 - year and 3 - year survival rates and toxicity were evaluated. Results Based on 36 - month follow - up, no significant difference of the short - term effective rates and 1 - year survival rates between the chemo- radiotherapy and radiotherapy groups were shown. However, there was significant difference of 3 -year survival rates between the chemoradiotherapy （78.3%） and radiotherapy （58.7%） groups （X2=4. 855 ,P=0. 027）. In additon, the acute toxicity （grade III and IV） in chemoradiotherapy group was worse than that in radiotherapy group （P 〈 0.05） but no significant difference of the delayed toxicity be- tween these two groups was discerned. Conclusion Chemoradiotherapy could better improve the 3 -year survival rate of cervical cancer with ⅡB～ⅢB stage than radiotherapy. Paclitaxel combined with cispla- tin have obvious long -term effects on medium -term and advanced cervical cancer with patient better tolerance and might have a promising prospect in the future clinical application.
出处
《遵义医学院学报》
2012年第5期420-422,428,共4页
Journal of Zunyi Medical University
关键词
宫颈癌
放射疗法
化学疗法
放化疗
临床疗效
cervical cancer
radiotherapy
chemotherapy
chemoradiotherapy
clinical effect
