摘要
目的探讨血清高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)增高对老年高血压人群新发心脑血管事件的影响。方法选择我院健康体检、年龄60～80岁的老年高血压人群5021例,行血清hs-CRP检测,从hs-CRP 0～5mg/L 3321例中随机选500例为正常组;从hs-CRP>5mg/L且≤10mg/L的1700例中随机选500例为增高组。随访3年,随访期每6个月收集1次新发心脑血管事件情况。比较新发心脑血管事件发生率。结果增高组新发心脑血管事件、脑梗死、非致死性急性心肌梗死发生率明显高于正常组,差异有统计学意义(14.4%vs 8.0%,7.0%vs 3.8%,5.2%vs 2.6%,P<0.05,P<0.01)。增高组累计无事件生存率明显低于正常组,随时间延长而逐渐明显,至随访3年结束时,生存率比较差异有统计学意义(P<0.05)。Cox比例风险回归分析显示,hs-CRP是心脑血管事件发生的独立危险因素,风险比3.67。结论 hs-CRP水平增高的老年高血压人群发生临床心脑血管事件的危险增加,尤其是脑梗死和心肌梗死的危险。
Objective To study the effect of hs-CRP on first cardio-cerebral vascular events in eld erly hypertensive patients. Methods Five thousand and twenty-one 60--80 years old hypertensive patients who underwent hs-CRP test were included in this study. Five hundred out of the 3321 patients with their hs-CRP being 0--5 mg/L served as a normal hs-CRP group and 500 out of the 1700 patients with their hs-CRP 〉5 mg/L but ≤10 mg/L served as a high hs-CRP group. The patients were followed up for 3 years during which the incidence of first cardio-cerebral vascular events was recorded every 6 months and compared. Results The incidence of first cardio-eerebral vascular events, cerebral infarction and non-fetal myocardial infarction was significantly higher in high hs-CRP group than in normal hs-CRP group（14. 4% vs 8. 0%,7. 0% vs 3. 8%,5.2% vs 2.6%,P〈0.05,P〈0.01）. The accumulated events-free survival rate was lower in high hs-CRP group than in normal hs-CRP group at the end of 3-year follow-up（P〈0.05）. Cox regression analysis showed that hs-CRP was the independent risk factor for cardio-cerebral vascular events. Conclusion The risk to occur cardio-cerebral vascular events,especially cerebral and myocardial infarction,increases in elderly hypertensive patients with a high hs-CRP level.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2013年第1期26-28,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
高血压
C反应蛋白质
心肌梗死
糖尿病
内皮
血管
脑梗死
hypertension
C-reactive protein
myocardia infarction
diabetes mellitus
endothelium, vascular ~ brain infarction
