摘要
目的通过检测毛细支气管炎(以下简称毛支)患儿血清白细胞介素-4(IL-4)、白细胞介素-8(IL-8)水平,研究其在发病中的临床意义及探讨相应的治疗对策。方法研究对象为106例住院毛支患儿(毛支组),随机选择其中40例为红霉素治疗组,31例为常规治疗组;另选34例正常小儿为对照组。采用双抗体夹心酶联免疫吸附法(ELISA),分别在毛支患儿急性期(入院当时)及恢复期(住院7 d后)检测血清IL-4、IL-8水平,正常小儿一次性检测。各组进行比较,并观察治疗7 d有效率。结果毛支组急性期血清IL-4水平与恢复期及对照组比较差异均无统计学意义(P>0.05);毛支组急性期IL-8水平高于恢复期,差异有统计学意义(P<0.05),与对照组比较,差异有统计学意义(P<0.05);红霉素治疗组恢复期血清IL-8水平低于常规治疗组,差异有统计学意义(P<0.05);红霉素治疗组的7天有效率高于常规治疗组(P<0.05)。结论 IL-4可能未参与毛支的发病,嗜酸性粒细胞并不是引起毛支的主要细胞,毛支可能不是过敏性炎症;IL-8参与毛支的病理过程,毛支气道炎症细胞可能以中性粒细胞为主;红霉素具有抗炎和免疫调节作用,可用于佐治毛支。
Objective To study the clinical significance of interleukin-4 and interleukin-8 in infants with bronchiolitis,by detecting their serum levels and to explore corresponding treatment countermeasure.Methods Object of study were 106 infants hospitalized with bronchiolitis（bronchiolitis group）,40 cases were randomly divided into erythromycin treatment group and 31 cases into conventional treatment group,another 34 cases of normal children were enrolled as control group.The serum levels of interleukin-4 and interleukin-8 were detected in infants with bronchiolitis during acute stage（at the time of admission） and convalescent stage（after 7 days of hospitalization） respectively,normal children were detected at a time.The groups were compared,and observed treatment efficiency for 7 days.Results The serum level of interleukin-4 in bronchiolitis group during acute stage had no significant diference in comparison with that during convalescent stage and that of normal control group（P0.05）.The serum level of interleukin-8 in bronchiolitis group during acute stage increased significantly compared with that during convalescent stage（P0.05）,and was much greater than that in normal control group（P0.05）.The serum level of interleukin-8 in erythromycin treatment group during convalescent stage was lower than that of the conventional treatment group during recovery stage（P0.05）;Therapeutic efficiency for 7 days of the erythromycin treatment group were significantly higher than that in the conventional treatment group（P0.05）.Conclusion Interleukin-4 may not participate in the pathogenesis of bronchiolitis,eosinophil may not be primary cells to cause bronchiolitis,bronchiolitis may not be allergic inflammation;interleukin-8 involved in the pathogenesis of bronchiolitis;inflammatory cells of airway in bronchiolitis are predominantly neutrophil;there are anti-inflammatory and immunomodulatory effects in erythromycin that can be used for treating the bronchiolitis.
出处
《临床医学》
CAS
2012年第12期25-27,共3页
Clinical Medicine
