摘要
目的:探讨幽门螺杆菌(Hp)感染对Hp相关性胃炎与胃黏膜癌前病变组织中转化生长因子βI型受体(TGF-βRI)表达水平的影响。方法:采用PCR-Hp-16SrRNA检测、Hp快速尿素酶试验(HpRUT)和14C-尿素呼气试验(14C-UBT)同步检测49例慢性浅表性胃炎(CSG)、39例重度肠化生(IM)和20例中重度不典型增生(Dys)患者胃黏膜组织中Hp感染情况,并以免疫组化方法分别检测其中TGF-βRI的表达。结果:各组患者Hp阳性率对比无显著性差异(χ2=3.825,P=0.148),CSG、IM到中度、重度Dys组Hp阳性者的TGF-βRI表达水平与病变的严重程度呈负相关(r=-0.707,P<0.001)。结论:Hp感染在Hp相关性胃炎与胃黏膜癌前病变中可明显下调TGF-βRI的表达。
Objective ： To explore the effects of Helicobacter pylori （Hp） infection on expression level of transforming growth factorβ type I receptor （ TGF-β RI） in gastric mucosa tissues of patients with Hp-related gastritis and gastric precancerous lesions. Methods： PCR-Hp-16SrRNA assay, Hp rapid u- rease test （HpRUT） and ^14C-urea breath test （^14C-UBT） were applied for synchronous detection of Hp infection condition of 49 patients with chronic superficial gastritis （group CSG）, 39 patients with se- vere intestinal metaplasia （group IM） and 20 patients with moderate or severe atypical hyperplasia （group Dys）. Immunohistochemical method was used to detect the TGF-β RI expression in gastric mu- cosa tissues of these patients. Results： No statistical difference was found in Hp positive rates among the three groups（χ2 = 3. 825, P =0. 148）. The TGF-β RI expression levels were negatively related with the severity of the lesions. Conclusions： Hp infection can significantly down-regulate the TGF-β RI expression in Hp-related gastritis and precancerous lesions.
出处
《贵阳医学院学报》
CAS
2012年第6期639-641,共3页
Journal of Guiyang Medical College
关键词
螺杆菌
幽门
胃炎
转化生长因子Β
Helicobacter pylori
gastritis
transforming growth factor beta
