摘要
目的探讨库存血G6PD活性对新生儿高胆红素血症换血治疗疗效影响。方法根据高胆红素血症患儿换血治疗时使用的库存血G6PD活性将190例患儿分为G6PD活性降低组(试验组)与G6PD活性正常组(对照组)。比较换血24h后血清总胆红素(TBil)水平与下降幅度,并对换血后光疗持续时间和再次换血患儿百分比进行比较。结果试验组换血24h后TBil水平高于对照组(t=5.74,P<0.05),下降幅度小于对照组(t=10.93,P<0.05);与对照组相比,试验组换血后光疗持续时间延长(t=7.14,P<0.05),再次换血患儿百分比升高(χ2=5.60,P<0.05)。结论以G6PD活性降低的库存血治疗新生儿高胆红素血症将导致换血后患儿胆红素水平下降较慢、光疗持续时间延长、再次换血的概率增加。
Objective To analyze the influence of glucose 6 phosphate dehydrogenase（G6PD） activity in banked blood on the therapeutic effects of exchange transfusion in neonatal hyperbilirubinemia. Methods 190 neonates with hyperbilirubinemia were divided into experiment group and control group according to the G6PD activity（reduced activity for experiment group and normal activity for control group） of banked blood used for the exchange transfusion. Serum total bilirubin（TBil） level and the drop of it at 24 hours after exchange,mean duration of phototherapy and repeated exchange neonates percentage were compared between the two groups. Results TBil level of experiment group was significantly higher than that of control group（t= 5.74, P〈0. 05） at 24 borers after exchange. TBil drop in experiment group was significantly lesser than that in control group（t= 10. 93, P〈0.05 ）. Compared with control group, the duration of phototherapy in experiment group was significantly longer（t=7.14, P〈0.05）. And the percent- age of neonates who underwent repeated exchange transfusion in experiment group was also significantly higher （x^2=5.60, P〈 0.05）. Conclusion In neonates with hyperbilirubinemia,exchange transfusion with reduced G6PD activity banked blood would have a lesser drop of TBil,a significantly longer phototherapy time and an increase probability of repeated exchange transfusion.
出处
《国际检验医学杂志》
CAS
2012年第18期2202-2203,共2页
International Journal of Laboratory Medicine
