摘要
背景:有研究表明脂肪来源干细胞具有组织修复能力,但将其应用于面部年轻化治疗中的报道较少。目的:将原代脂肪来源干细胞辅助颗粒脂肪移植,联合颞部小切口除皱术应用于接受面部年轻化治疗的患者,观察该治疗方法的临床效果。方法:回顾分析解放军沈阳军区总医院整形外在2009年6月至2011年8月的20例来院接受面部除皱治疗女性患者的资料。其中接受自体脂肪来源干细胞辅助治疗的患者10例设为治疗组,单纯接受除皱术患者10例设为对照组。采用皱纹评分的方法,结合VISIA专业皮肤图像分析系统对患者治疗后的斑点、毛孔、皱纹、纹理进行检测,对所得数据进行比较分析。结果与结论:治疗后随访3-15个月,两组治疗前后皱纹评分差异无显著性意义,说明两组治疗患者在皱纹的改善方面效果没有明显区别。治疗前、后的VISIA皮肤检测结果显示,治疗组的毛孔和斑点改善率优于对照组(P<0.05),纹理和皱纹改善率差异无显著性意义(P>0.05)。证实,脂肪来源干细胞辅助下的面部年轻化治疗与单纯除皱疗法在面部年轻化治疗的除皱效果基本一致,但治疗后患者的皮肤毛孔、斑点改善效果明显更好。
BACKGROUND： Several studies have demonstrated that adipose-derived stem cells have tissue reparative ability, but few studies have been reported about application of adipose-derived stem cells in facial rejuvenation treatment. OBJECTIVE： Primary adipose-derived stem cells were isolated from human liposuction aspirates and added into adipose tissue. The compounds were injected into the face of patients who underwent face lifting through tempus incision. The aesthetic effects were observed. METHODS： Clinical data of 20 female patients who underwent fact lifting between June 2009 and August 2011 in Department of Plastic Surgery, General Hospital of Shenyang Military Command were retrospectively analyzed. Ten patients who received autologous adipose-derived stem cells assisted treatment were included in the treatment group and the remaining 10 patients who underwent simple facial lifting were included in the control group. The therapeutic effects were evaluated using score of wrinkle standard and VISIA professional skin image analysis system in terms of freckle, pores, wrinkle, and skin texture. RESULTS AND CONCLUSION： Twenty patients were followed by 3-15 months. There was no significant difference in the score of wrinkle standard between treatment and control groups （P 〉 0.05）. It suggests that autologous adipose-derived stem cells assisted treatment and simple face lifting have no obvious difference in reducing the wrinkles. VISIA skin detection results showed that there was a greater improvement in freckle and pores in the treatment group compared with the control group （P 〈 0.05） and there was no significant difference in improvement in skin texture and wrinkles （P 〉 0.05）. These results suggest that autologous adipose-derived stem cells assisted treatment and simple face lifting have similar effects in facial rejuvenation, but the former exhibits better effects than the latter one on improving pores and freckle.
出处
《中国组织工程研究》
CAS
CSCD
2012年第49期9257-9264,共8页
Chinese Journal of Tissue Engineering Research
基金
辽宁省科技攻关计划项目(2009225019)~~
