摘要
目的探讨腹腔镜下胆管手术对机体的应激及体液免疫功能的影响。方法将急性结石性胆囊炎患者80例根据治疗方法的不同分为治疗组与对照组,各40例,治疗组患者采用腹腔镜下手术治疗,对照组患者采用传统开腹治疗。对两组治疗效果进行观察比较。结果治疗组的术后引流量、肛门排气时间、下床活动时间与住院时间均明显少于对照组(均P<0.05)。两组术后第1天C反应蛋白(CRP)、白介素6(IL-6)和肿瘤坏死因子α(TNF-α)值均有明显提高(均P<0.05),治疗组到术后第3天逐渐恢复,而对照组无明显变化。治疗组在三个时间点CD3与CD4值变化差异不明显,而对照组则有明显波动(P<0.05)。结论腹腔镜胆管手术比传统开放手术除了能够有利于术后恢复,同时在应激保护与免疫功能保护上更具优势,值得推广应用。
Objective To investigate the effect of laparoscopic biliary tract surgery on the body＇s stress and humoral immune function.Methods 80 cases of patients with acute cholecystitis were divided into treatment group（40 cases） and control group（40 cases） according to treatment ways,the treatment group was treated with laparoscopic surgery,and the control group was treated with conventional open therapy.The treatment effects of two groups were observed and compared.Results The postoperative drainage,flatus,ambulation time and hospital stay of the treatment group were significantly less than those of the control group（all P 0.05）.The C-reactive protein（CRP）,Interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） values of the first postoperative day 1 were improved significantly（all P 0.05）,and the treatment group were gradual recovery of the third postoperative day,while there was no significant changed in the control group.CD3 and CD4 values were not obvious difference in the three time points in the treatment group,but there were significant fluctuations in the control group（P 0.05）.Conclusion Laparoscopic biliary tract surgery in addition has beneficial to postoperative recovery and has an advantage in stress protection and the protection of immune function which should be widely applied.
出处
《中国医药导报》
CAS
2013年第1期44-45,48,共3页
China Medical Herald
基金
广东省湛江市科技计划项目(项目编号:szwzy201110)
关键词
腹腔镜
胆管手术
应激
免疫
Laparoscopy
Biliary tract surgery
Stress
Immune
