摘要
目的通过分析甲状腺良恶性结节CT灌注成像各个参数的差异,探讨64层螺旋CT灌注成像在甲状腺病变诊断及鉴别诊断中的临床应用价值。方法对51例因甲状腺疾病拟手术治疗的患者行术前甲状腺CT平扫定位+灌注成像检查。良性结节40例,其中甲状腺肿20例,甲状腺腺瘤20例;恶性结节11例,全部是甲状腺癌。计算各灌注参数的平均值,包括血容量(BV)、血流量(BF)、灌注达峰时间(TTP)和毛细血管表面通透性(PS)的平均值,并进行统计学分析。结果多层螺旋CT甲状腺灌注图像可以清晰显示甲状腺病变的大小和轮廓,并计算病变内部的组织灌注参数。良性结节组BF(249.89±43.95)ml·min-1.100g-1、BV值(28.69±6.17)ml·100g-1、TTP值(15.21±2.60)s、PS值(39.30±7.21)ml·min-1.100g-1。恶性结节组BF值(258.80±44.47)ml·min-1.100g-1、BV值(28.15±3.02)ml·100g-1、TTP值(13.56±1.25)s、PS值(66.63±12.07)ml·min-1.100g-1。甲状腺良恶性结节的BV值及BF值差异无统计学意义(P=0.779;P=0.555),PS值及TTP值的差异具有统计学意义(P=0.000;P=0.048)。甲状腺良恶性结节时间-密度曲线(TDC)的波形不同,良性结节多表现为缓升缓降(Ⅲ)型,而恶性结节多表现为缓升平台(Ⅱ)型。结论 MSCT灌注成像在甲状腺良恶性结节鉴别诊断方面可提供一定的补充信息,PS在鉴别诊断中价值较大,TDC有一定参考价值。
Objective To assess the value of 64 Slice CT perfusion imaging in diagnosis and differential diagnosis of thyroid diseases by analyzing the difference of perfusion imaging parameters.Methods 51 patients with thyroid disease received 64 slice CT.40 cases were benign nodules,including 20 cases of nodular goiter,20 cases of thyroid adenoma.11 cases were malignant nodules which were thyroid carcinoma,CT perfusion parameters were calculated.Results Thyroid perfusion images could clearly show the size and contour of thyroid lesions.In benign nodule group,the BF was（249.89 ±43.95） ml·min-1·100g-1,BV value was（28.69 ± 6.17） ml·100g-1,TTP value was（15.21± 2.60） s,and PS was（39.30 ± 7.21） ml·min-1·100g-1.In malignant nodules group,the BF was（258.80±44.47） ml·min-1·100g-1,BV value was（28.15±3.02） ml·100g-1,TTP value was（13.56±1.25）s,and PS value was（66.63±12.07） ml·min-1·100g-1.There was no significant difference in BV and BF values between two groups（P=0.779;P=0.555）,there was significant difference in the PS values and TTP（P=0.000;P=0.048）.The TDC shape was different between benign and malignant thyroid nodules.The TDC type of benign nodules was ramp slow down（Ⅲ）,and the malignant nodules was depicted as the ramp platform（Ⅱ）.Conclusion MSCT perfusion imaging can provide some information in differential diagnosis of benign and malignant thyroid nodules.The PS value is useful and TDC has some reference value in differential diagnosis of thyroid nodules.
出处
《临床放射学杂志》
CSCD
北大核心
2013年第1期52-55,共4页
Journal of Clinical Radiology
