摘要
目的检测大肠癌组织中NRP-2、NRP-1的表达情况,探讨NRP-2、NRP-1的表达与大肠癌淋巴结转移的关系,以期揭示NRP-2与NRP-1在大肠癌发生和发展过程中的作用。方法采用免疫组化法检测55例大肠癌患者大肠癌组织、癌旁组织中NRP-2、NRP-1的表达情况,并分析NRP-2、NRP-1的表达与大肠癌淋巴结转移的相关性。结果 (1)大肠癌组织中NRP-2的阳性表达率为81.8%,癌旁组织中的阳性表达率为14.5%,差异有统计学意义(χ2=58.49,P<0.01);大肠癌组织中NRP-2高表达组的淋巴结转移阳性例数显著多于NRP-2低表达组(χ2=10.69,P<0.01)。(2)大肠癌组织中NRP-1的阳性表达率为70.9%,癌旁组织中的阳性表达率为25.5%,差异有统计学意义(χ2=22.76,P<0.01);大肠癌组织中NRP-1高表达组的淋巴结转移阳性例数显著多于NRP-1低表达组(χ2=7.73,P<0.01)。(3)大肠癌组织中NRP-2、NRP-1均为高表达的患者淋巴结转移率显著高于均为低表达者(χ2=10.76,P<0.01)。结论 NRP-2、NRP-1的表达可能与大肠癌的发生和发展密切相关,并且可能有协同作用。
Objective To detect the expression of NRP 2 and NRP-1 in human colorectal carcinoma and the correlation between the expression of NRP-2, NRP-1 and lymph node metastasis of colorectal carcinoma, and to investigate the role of NRP-2, NRP-1 in the process of the generation and development of colorectal carcinoma. Methods The expression of NRP-2,NRP-1 in the parenchymatous and the surrounding tissue of malignancies was detected. The correlation between the expression of NRP-2, NRP-1 and lymph node metastasis of colorectal carcinoma was analyzed. Results 1. The positive expression ratio of NRP-2 was 81.8% in 55 examples of colorectal carcinoma tissue and 14.50/oo in the surrounding tissue of malignancies,and the difference had statistical sig- nificance（X^2 =22.76 ,P〈0.01）. There were much more positive cases of lymph node metastasis in the high expression groups of NRP-2 than the low expression groups of NRP-2（X^2= 10.69 ,P〈0.01）. 2. The positive expression ratios of NRP-1 were 70.90% in 55 examples of colorectal carcinoma tissue and 25.5% in the surrounding tissue of malignancies, and the difference had statistical significance（X^2= 22.76,P（0.01）. And also there were much more positive cases of lymph node metastasis in the high expression groups of NRP-1 than the low expression groups of NRP-1 （X^2= 7.73,P（0.01）. 3. The rate of lymph node metastasis in patients that both NRP-2 and NRP 1 were highly expressed was superior to that of low expression of both. Conclusion Both NRP-2 and NRP-1 were overexpressed in colorectal carcinoma,and the positive rate of lymph node metastasis in patients that both NRP-2 and NRP-1 were overexpressed was far superior to the positive rate of low expression of both. Therefor, the expression of NRP 2 and NRP-1 may be statistically positively correlated with the generation and development of eolorectal carcinoma,and which may have a synergetic effection.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第4期382-384,387,共4页
Chongqing medicine
基金
河北省科技厅资助项目(10276115D)
