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微小RNA与动脉粥样硬化的研究进展 被引量：8

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摘要 微小RNA（MicroRNA，miRNA）是一类在人体广泛分布的非编码RNA，主要通过与mRNA结合，导致其翻译受到抑制或引起mRNA降解，而在转录水平影响基因的表达。近些年有学者发现，miRNA参与动脉粥样硬化的发生、发展。本研究阐述了在动脉粥样硬化过程中，与平滑肌细胞、内皮细胞、单核／巨噬细胞密切相关的miRNA及作用。
作者 孙婷婷 罗善顺 韩辉
机构地区 哈尔滨医科大学附属第一医院干部一病房
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2013年第2期211-212,共2页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 国家自然科学基金(81070216) 国家教育部春晖计划(Z2010007) 黑龙江省教育厅海外学人重点项目(1155hz002) 哈医大一院院基金资助项目(2009L01)
关键词 微RNAS 动脉粥样硬化 内皮细胞 单核细胞 巨噬细胞 平滑肌细胞
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献15

  • 1Borchert GM, Lanier W, Davidson BL. RNA polymerase fII transcribes human microRNAs. Nature Structural and Molec- ular Biology,2006, la : 1097-1101.
  • 2Silvestri P, DiRusso C, Rigattieri S, et al. MicroRNAs and is chemic heart disease;towards a better comprehension of path ogenesis,new diagnostic tools and new therapeutic targets. Recent Patents on Cardiovascular Drug Discovery, 2009,4: 109 118.
  • 3Kishore R, Krishnamurthy P, Losordo DW. Losordo. Career moves:induced pluripotent cells from human aortic smooth muscle cells can efficiently redifferentiate into parental phe- notype. Circ Res, 2010,106 : 7-9.
  • 4Wang YS, Wang HY, Liao YC, et al. MicroRNA-195 regu- lates vascular smooth muscle cell phenotypes and prevents neointimal formation. Cardiovasc Res,2012,95:517-526.
  • 5Hergenreider E, Heydt S,Tr:guer K, et al. Atheroprotectivc communication between endothelial cells and smooth muscle cells through miRNAs. Hergenreider E Nat Cell Biol, 2012, 14,249-256.
  • 6Cheng Y, Liu X, Yang J, et al. MicroRNA 145, a novel smooth muscle cell phenotypic marker and modulator, controls vascu lar neointimal lesion formation. Circ Res, 2009, 1 05 : 158-166.
  • 7Cordes KR,Sheehy NT,White MP,ct al. miR 145 and miR 143 regulate smooth muscle cell fate and plasticity. Nature, 2009,460:705-710.
  • 8Liu X, Cheng Y, Zhang S, et ak A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res, 2009,104:476-487.
  • 9Leeper NJ,Raiesdana A, Kojima Y, et al. MicroRNA 26a is a novel regulator of vascular smooth muscle cell function. J Cell Physiol, 2011,226 : 1035 1043.
  • 10熊玮,董少红,袁建辉,李江华,刘建军,徐新云.MiRNA-146a通过NF-κB依赖的途径促进血管平滑肌细胞增殖[J].南方医科大学学报,2012,32(2):270-273. 被引量：11

二级参考文献24

  • 1Esteller M.Non-coding RNAs in human disease[J].Nat Rev Genet, 2011,12(12):861-74.
  • 2Bandiera S,Hatem E,Lyonnet S,et al.microRNAs in diseases: from candidate to modifier genes[J].Clin Genet,2010,77(4): 306-13.
  • 3Bhaumik D,Scott GK,Schokrpur S,et al.Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells[J].Oncogene,2008,27 (42):5643-7.
  • 4Li L,Chen XP,Li YJ.MicroRNA-146a and human disease[J]. Scand J Immunol,2010,71(4):227-31.
  • 5Taganov KD,Boldin MP,Chang KJ,et al.NF-kappaB-dependent induction of microRNA miR-146,an inhibitor targeted to signaling proteins of innate immune responses[J].Proc Natl Acad Sci U S A, 2006,103(33):12481-6.
  • 6Pauley KM,Satoh M,Chan AL,et al.Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients[J].Arthritis Res Ther,2008,10(4):R101.
  • 7Pacifico F,Crescenzi E,Mellone S,et al.Nuclear factor-{kappa } B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a[J].J Clin Endocrinol Metab,2010,95(3):1421-30.
  • 8Wang JF,Yu ML,Yu G,et al.Serum miR-146a and miR-223 as potential new biomarkers for sepsis[J].Biochem Biophys Res Commun,2010,394(1):184-8.
  • 9Guo M,Mao X,Ji Q,et al.miR-146a in PBMCs modulates Thl function in patients with acute coronary syndrome[J].Immunol Cell Biol,2010,88(5):555-64.
  • 10Ji R,Cheng Y,Yue J,et al.MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation[J].Circ Res,2007,100(11): 1579-88.

共引文献19

同被引文献43

  • 1徐燕,杨爱东,唐靖一,张玮,严世芸（指导）.严世芸治疗充血性心力衰竭的经验[J].上海中医药杂志,2006,40(10):10-11. 被引量：32
  • 2Okoniewski M J,Hey Y,Pepper SD,et al.High correspondence between Affymetrix exon and standard expression arrays[J].Biotechniques,2007,42(2):181-185.
  • 3Sarela AI,Macadam RC,Farmery SM,et al.Expression of the antiapoptosis gene,survivin,predicts death from recurrent colorectal carcinoma[J].Gut,2000,46(5):645-650.
  • 4Lu B,Mu Y,Cao C,et al.Survivin as a therapeutic target for radiation sensitization in lung cancer[J].Cancer Res,2004,64 (8):2840-2845.
  • 5Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin14[J].Cell,1993,75(5):843-854.
  • 6Krol J,Loedige I,Filipowicz W.The widespread regulation of microRNA biogenesis,function and decay[J].Nat Rev Genet,2010,11(9):597-610.
  • 7Rachagani S,Kumar S,Batra SK.MicroRNA in pancreatic cancer:pathological,diagnostic and therapeutic implications[J].Cancer Lett,2010,292(1):8-16.
  • 8Alvarez-Garcia I,Miska EA.MicroRNA functions in animal development and human disease[J].Development,2005,132 (2):4653-4662.
  • 9Banaudha KK,Verma M.The role of microRNAs in the management of liver cancer[J].Methods Mol Biol,2012,863:241-251.
  • 10Hong L,Han Y,Zhang H,et al.The prognostic and chemotherapeutic value of miR-296 in esophageal squamous cell carcinoma[J].Ann Surg,2010,251(6):1056-1063.

引证文献8

二级引证文献35

中华老年心脑血管病杂志
2013年 第2期

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