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新型口服抗凝药物在房颤治疗及预后方面的研究进展 被引量:3

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摘要 华法林是防治房颤卒中最有效抗凝药物。出血、频繁监测INR值等缺点限制了华法林临床使用率。新近一些新型口服抗凝药物的研究不断涌现,许多研究结果表明这些新型口服抗凝药物在预防卒中的作用中不劣于华法林,且出血风险可能较华法林低,故有望取代华法林这一传统抗凝药。本文系统回顾近年有关口服抗凝药的相关研究,并将这些研究进展综述如下。
出处 《中国实用医药》 2013年第2期244-245,共2页 China Practical Medicine
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  • 1Wolf P A,Abbott R D,Kannel W B. Atrial fibrillation as an independent risk factor for stroke:the Framingham Study[J].Stroke,1991,(08):983-988.
  • 2Fang M C,Go A S,Chang Y. Warfarin discontinuation after starting warfarin for atrial fibrillation[J].Circ Cardiovasc Qual Outcomes,2010,(06):624-631.
  • 3Poller L,Jespersen J,Ibrahim S. Dabigatran versus warfarin in pat ients withatrialfibrillation[J].New England Journal of Medicine,2009,(27):2673-426745.
  • 4Perzborn E,Strassburger J,Wilmen A. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral,direct Factor Xa inhibitor[J].Journal of Thrombosis and Haemostasis,2005,(03):514-521.
  • 5Mueck W,Becka M,Kubitza D. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral,direct factor xa inhibitor-in healthy subjects[J].International Journal of Clinical Pharmacology and Therapeutics,2007,(06):335-344.
  • 6Patel M R,Mahaffey K W,Garg J. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation[J].New England Journal of Medicine,2011,(10):883-891.
  • 7Eikelboom J W,Weitz J I. New anticoagulants[J].Circulation,2010,(13):1523-1532.
  • 8Granger C B,Alexander J H,Mcmurray J J. Apixaban versus warfarin in patients with atrial fibrillation[J].New England Journal of Medicine,2011,(11):981-992.

同被引文献42

  • 1武忠弼.病理学[M].北京:人民卫生出版社,1996.90.
  • 2Spencer F A, Emery C, Lessard D,et al. The Worcester venous tbrombo- embolism study:a population - based study of the clinical epidemiology of venous thromboembolism[ J]. J Gen Intern Med ,2006,21 (7) :792 - 727.
  • 3Pinto D J, Smahheer J M, Cheney D L,et al. FactorXa lnhibitors:next - Generation Antithrombotic Agents [ J ]. J Med Chem, 2010,53 ( 17 ) : 6243 - 6274.
  • 4Alemida L, Falcao A, Vazda Silva M, et al. Effect of nebicapone on the pharmacokineties and pharmacodynamics of warfarin in healthy subljects [ J]. Eur J Clin Pharmacol,2008,64(10) :961.
  • 5A1 Sallami H,Ferguson R, Wilkins G,et al. Bleeding events in patients receiving enoxaparin for the management of non - ST - e|evation acute coronary syndrome at Dunedin Public Hospital[ J]. New Zealand medical journal ,2008,121 ( 1285 ) :87.
  • 6梁森,吴明华,张秀胜,等.心房颤动患者预防卒中的药物治疗进展[J].中华临床医师杂志,2012,6(18):5595-5597.
  • 7Vchiyama S, Ibayasli S, Matsumoto M,et al. Dabigatran and faetorXa in- hibitor for stroke prevention in patients with nonvalvular atrial fibrillation [ J]. J Strike Cerebrovase Dis,2012,21 : 165 - 173.
  • 8Johansson S,Cullberg M, Eriksson U G,et al. single dose pharmacolei- nerves, phatmacodynamics and safety of AZD0837, a novel oral direct thrombin inhibitor, in young healthy male subjects[ J]. Int J Clin Phar- macol Ther,2012,49 : 258 - 267.
  • 9Mega J L,Braunwald E,Wiviott S D,et al. Rivaroxaban in patients with a recent acute coronary syndrome[J]. N Engl J Med,2012,366( 1 ) :9 - 19.
  • 10Connolly SJ,Wallentin L,Ezekowitz MD,et al.The long-term multicenter observational study of Dabigatran Treatment in Patients With Atrial Fibrillation(RELY-ABLE)Study[J].Circulation,2013,128(3):237-243.

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