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促凋亡基因Smac在急性淋巴细胞白血病患儿中表达的意义 被引量：2

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摘要 目的:探讨促凋亡基因Smac在儿童急性淋巴细胞白血病(ALL)中的表达及其临床意义。方法:收集50例ALL患儿及25例非恶性血液病患儿的骨髓,采用RT-PCR技术检测Smac基因mRNA的表达情况。结果:Smac基因在初治ALL患儿骨髓中的表达均高于完全缓解组(P<0.05)和对照组(P<0.05),与缓解后复发组比较,差异无统计学意义(P>0.05)。初治的ALL骨髓Smac表达阳性(Smac+)患儿复发率明显高于Smac表达阴性(Smac-)患儿,差异有统计学意义(P<0.05)。结论:提示在儿童ALL的发生发展过程中促凋亡基因Smac起着重要作用,并且检测Smac基因可作为判断ALL患儿预后的因素。
作者 王晓欢 武坚锐 郝国平 史红鱼
机构地区 山西省儿童医院
出处 《临床医药实践》 2013年第2期110-112,共3页 Proceeding of Clinical Medicine
关键词 SMAC 急性淋巴细胞白血病 儿童
分类号 R733.7 [医药卫生—肿瘤]
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同被引文献18

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临床医药实践
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