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激素替代治疗与抗抑郁药物改善更年期症状和情感障碍的效果比较 被引量:5

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摘要 目的研究对比激素替代治疗与抗抑郁药物改善更年期症状和情感障碍的临床效果。方法选择临床表现为中度以上更年期症状,同时合并有情感障碍的患者120例,随机平均分为三组,雌激素组(40例)给予口服0.25mg已烯雌酚治疗,隔天服用;舍曲林组(40例)给予1:3服20mg舍曲林治疗,1次/d;对照组(40例)给予口服安慰剂20mg维生素B,治疗,1次/d。三组均治疗6周,分别在治疗前、治疗第4周、第6周对三组患者应用症状自评法、综合医院焦虑/抑郁情绪测定量表(HAD)以及汉密尔顿-抑郁量表(HAM—D)进行疗效评定。结果治疗后,雌激素组更年期血管运动症状缓解率(92.5%)显著优于舍曲林组(40.0%)(Х^2=4.82,P〈0.05);舍曲林组抑郁和焦虑症状评分下降显著优于雌激素组(t=10.31、11.08,P〈0.05)。结论抗抑郁药物在治疗更年期症状和情感障碍方面临床疗效确切,值得临床推广和普及。
作者 刘玉洁
出处 《中国基层医药》 CAS 2013年第2期277-279,共3页 Chinese Journal of Primary Medicine and Pharmacy
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