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新疆哈萨克族食管鳞癌中HLA-G的表达及其意义 被引量：2

Expression and Significance of HLA-G in Kazak Patients with Esophageal Squamous Cell Carcinoma
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摘要 目的探讨人类白细胞抗原-G(human leucocyte antigen,HLA-G)在新疆哈萨克族食管鳞癌中的表达及临床意义。方法应用免疫组织化学SP法对30例哈族食管鳞癌及20例癌旁正常组织中HLA-G的表达进行检测。结果哈族食管鳞癌组织中HLA-G的表达率为66.7%,明显高于癌旁正常组织20.0%,差异具有统计学意义(P<0.05);HLA-G的表达与哈族食管癌浸润深度和临床分期关系密切(P均<0.05),而与患者年龄、性别、食管癌发生部位、分化程度和淋巴结转移无明显相关性(P均>0.05)。结论 HLA-G的高表达可能在新疆哈族食管鳞癌的发生发展中起重要作用。 Objective To investigate the expression and clinical significance of HLA-G in Xinjiang Kazak patients with esophageal squamous cell carcinoma（ESCC）.Methods The expression of HLA-G was detected using SP immunohistochemical staining in 30 ESCC and 20 cases of tumor adjacent normal tissues.Results The positive rate of HLA-G expression in ESCC was 66.7%（20/30）,significantly higher than that in tumor adjacent normal tissues（20%）（P〈0.05）.The positive rate of HLA-G was closely related with depth of invasion and clinical stage（P〈0.05 for all）,but not with age,gender,tumor location,histologic grade and lymphnode metastasis（P〈0.05 for all）.Conclusion The significantly over expression of HLA-G might play a key role in the pathogenesis of Kazak ESCC in Kazak population.
作者 刘杨正 胡建明 李锋 李玲 闫小龙 李鑫 陈文娟 熊洋洋
机构地区 石河子大学医学院预防医学系新疆地方与民族高发病省部共建教育部重点实验室 石河子大学医学院病理教研室 石河子大学生命科学学院
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2013年第2期164-167,共4页 Cancer Research on Prevention and Treatment
基金 国家"十一五"科技支撑计划资助课题(2009BAI8203) 国际科技交流与合作项目资助课题(2010DFB34100)
关键词 食管鳞癌 人类白细胞抗原-G 免疫组织化学 哈萨克族 Esophageal squamous cell carcinoma Human leucocyte antigen Immunohistochemistry Kazak
分类号 R735.1 [医药卫生—肿瘤]
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肿瘤防治研究
2013年 第2期

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