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Wnt和相关信号通路交互作用在非小细胞肺癌发生发展中的作用

Interaction of Wnt and the related signaling pathways in carcinogenesis and progression of non-small cell lung cancer
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摘要 Wnt信号通路和相关信号通路(如EGFR,Notch,Hedgehog等信号通路)在肿瘤发生发展中起着重要的作用。研究证实,Wnt与EGFR及Notch通路的交互在肺癌中起重要作用,Wnt和Hedgehog信号通路交互在宫颈癌中起重要作用。本文主要就Wnt信号通路和EGFR,Notch,Hedgehog信号通路在非小细胞肺癌发生发展中的作用及其相互联系进行综述。 Wnt and its related signaling pathways （ EGFR, Hedgehog, Notch signaling pathways ） are crucial in tumor formation and progression. Studies have shown that the interaction of Wnt pathway with EGFR and Notch pathway played an important role in lung cancer, as well as the interaction of Wnt pathway with Hedgehog pathway had significant influence in development of cervical cancer. This article reviewed research advances in the function and interaction of Wnt and the relat- ed signaling pathways in non - small cell lung cancer.
作者 李玉婵 孙杰
机构地区 广东医学院附属医院
出处 《药学研究》 CAS 2013年第2期106-108,共3页 Journal of Pharmaceutical Research
关键词 非小细胞肺癌 WNT信号通路 通路交互作用 Non - small cell lung cancer Wnt signaling pathway Cross - talking
分类号 R979.1 [医药卫生—药品]
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参考文献24

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