摘要
20-羟-二十烷四烯酸(20-hydroxyeicosatetraenoic acid,20-HETE)是花生四烯酸的细胞色素P-450代谢途径的一个重要代谢产物。近年来研究发现20-HETE对血管内皮细胞发挥重要的生理和病理生理作用。20-HETE可激活内皮细胞烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleoti-de phosphate,NADPH)氧化酶系统和核因子-кB(nuclear factor-кB,NF-кB)通路发挥氧化应激和促炎作用;20-HETE可介导血管内皮细胞内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)的解离、降低NO的生物利用度及诱导血管紧张素转换酶,调节血管的舒张和收缩功能;20-HETE还可促进内皮细胞的增生而促进血管新生。但国内对20-HETE研究甚少,因此本文对近年来国际上关于20-HETE对血管内皮细胞的研究作一综述。
20-hydroxyeicosatetraenoic acid （20-HETE） is an important metabolite of cytochrome P-450 pathway of arachidonic acid（AA）. It has been demonstrated recently that 20-HETE played a significant role in physiology and pathophysiology process of vascular endothelium （EC）. 20-HETE exerted oxida- tive stress and pro-inflammation effect through nicotinamide adenine dinucleotide phosphate （NADPH） oxidase system and nuclear factor-KB （NF-KB） pathway; it took part in the modulation of vascular dila- tion and constriction by mediating dissociation of endothelial nitric oxide synthase （eNOS） and inducing angiotensin converting enzyme in EC ; it also promoted the proliferation of EC and angiogenesis. Howev- er, the domestic study about 20-HETE is rare. Therefore, the present paper reviewed the recent interna- tional studies of 20-HETE on EC.
出处
《生理科学进展》
CAS
CSCD
北大核心
2013年第1期1-5,共5页
Progress in Physiological Sciences
