摘要
目的均匀设计法优选连翘超微粉碎工艺技术参数。方法采用单因素考察各粉碎工艺参数的范围,结合均匀设计、逐步回归法优选超微粉碎工艺条件。结果逐步回归方程为Y=41.083-1.029X2,r=0.9998;参照粉碎工艺参数范围及生产实际,选择连翘超微粉碎工艺条件为粉碎时间18min,温度?10～10℃,水分5%～9%,介质填充率60%～70%,预测粒径D50为22.56μm,验证粒径D50为22.81μm。结论超微粉碎工艺条件参数与粒径相关性良好,均匀设计法对超微粉碎工艺具有较好的指导意义。
Objective To optimize the technical parameters of ultramicro comminution for Forsythia suspensa by uniform design.Methods The scope of each comminution technology parameter was studied by using single-factor test,and the condition of ultramicro comminution technology was optimized by uniform design and stepwise regression.Results The stepwise regression equation was Y = 41.083-1.029X2,r = 0.999 8;According to the scope of each comminution technology parameter and the actual production conditions,the optimized technical conditions of ultramicro powder grinding of Forsythia suspense were as follows：grinding time 18 min,grinding temperature ？10—10 ℃,water content 5%—9%,medium filling rate 60%—70%,predicted particle diameter D50 22.56 μm,validation particle diameter D50 22.81 μm,which revealed that this equation had good practical guidance.Conclusion The relationship between ultramicro comminution technical parameters and particle diameter is very good,and the uniform design could guide the ultramicro comminution technology.
出处
《药物评价研究》
CAS
2013年第1期45-47,共3页
Drug Evaluation Research
基金
湖南省科技厅重点项目(06FJ2005)
关键词
连翘
超微粉碎
均匀设计
粒径
逐步回归
Forsythia suspensa（Thunb.） Vahl
ultramicro comminution
uniform design
particle diameter
stepwise regression
