摘要
以水杨酸和乙酸酐为原料,自制的S2O28-/Sb2O3-SnO2-La3+固体超强酸为催化剂合成了阿司匹林。考察了催化剂的制备条件及合成的最佳条件。结果表明,当n(水杨酸)∶n(乙酸酐)=1∶1、反应时间为25 min、反应温度为70℃、催化剂用量为水杨酸的15%,此时阿司匹林的收率可达81.33%。
Using salicylic acid and acetic anhydride as raw materials, homemade S2O8^2-/Sb203 -SnO2 -La3＋ solid super acid as catalyst, the aspirin was synthesized. The preparation conditions and the optimum synthesis conditions were explored. The results showed that when n （ salicylic acid） ： n （ acetic anhydride） = 1 ： 1.2, the reaction time was 25 min, reaction temperature was 70℃, and catalyst dosage for 15% of salicylic acid, the aspirin yield was up to 81.33%.
出处
《广州化工》
CAS
2013年第4期66-68,共3页
GuangZhou Chemical Industry
基金
贵州省科学技术基金项目([2010]2128)
