摘要
[目的]4g讨支原体肺炎（MPP）患儿血清中细胞因子白细胞介素-8（IL-8），白细胞介素-12（IL-12）水平以及高敏C-反应蛋白（hs-CRP）、免疫球蛋白（Ig）和血清补体（C）的变化及其临床意义。【方法】收集MPP患儿50例，分为重症组、轻症组。健康儿童42例作为对照组；用ELlSA法测定MPP患儿急性期、恢复期及对照组儿童血清IL-8、IL-12的水平，用血浆蛋白分析仪速率散射比浊法测定hs-CRP，Ig和C含量。【结果】在急性期和恢复期MPP惠儿血清IL-12含量明显低于正常对照组（P〈0．05）；而血清IL-8含量在急性期明显高于正常对照组（Pd0．01）。重症组患儿血清中IL-12明显低于轻症组，而血清中IL-8较轻症组高（P均〈0．01）。急性期MPP患儿血清IgM，IgG与对照组相比明显升高（P均〈0．01）；而IgA明显降低（P〈0．05）。急性期MPP患儿hs—CRP、C3、C4与对照组比较显著升高（分别为P〈0．01、P〈0．01、P〈0．05）。重症组患儿血清中IgM，IgG与轻症组相比明显升高（P均〈0．01）；IgA与轻症组相比明显降低（Pd0．05）；重症组患儿血清中hs-CRP、C3、C4与轻症组相比明显升高（P均〈0．01）。【结论】检测相关血清炎性细胞因子对判定MPP患儿的病情和预后有较高的临床应用价值。
[Objective]To explore the changes of serum interleukin-8 （IL-8）, interleukin-lZ （IL-12）, high sensitive c-reactive protein（hs-CRP）, immunoglobulin（Ig） and serum complement（C） in children with myco- plasma pneumonia（MPP） and their significance. [Methods] Fifty children with MPP were collected and divid- ed into severe group and mild group. Forty two healthy children were chosen as control group. ELISA was used to determine the serum levels of IL 8 and IL-12 in children with MPP during acute period, mild period and convalescence period and children in control group. Plasma protein analyzer rate scattering ratio turbidime- try was used to determine the levels of hs-CRP, Ig and C. [Results]Serum IL-12 of MPP children at acute pe- riod and convalescence period was obviously lower than that in control group（ P d0.05）, while serum IL-8 of MMP children at acute period was obviously higher than that in control group（ P ＊~0.01）. Serum IL-12 in se- vere group was obviously lower than that in mild group, while serum IL-8 in severe group was higher than that in mild group（all P d0.01）. Compared with control group, serum IgM and IgG in MMP children at severe pe- riod increased obviously（all P d0.01）, whereas IgA decreased obviously（ P d0.05）. Compared with control group, serum hs-CRP, C3 and C4 in MPP children at acute period increased obviously（ P d0.01, P d0.01 and P d0.05, respectively）. Compared with mild group, serum IgM and IgG of children in severe group in- creased significantly（all P d0.01）, while IgA decreased significantly（ P d0.05）. Compared with mild group, serum hs CRP, C3 and C4 in children of severe group increased obviously（all P 〈0.01）. [Conclusion]The de- tection of the related inflammatory cytokines has high clinical application value for determining the condition and prognosis of MPP children.
出处
《医学临床研究》
CAS
2013年第1期114-116,119,共4页
Journal of Clinical Research
关键词
肺炎
支原体
血液
pneumonia, mycoplasma
