摘要
目的观察乌梅丸对Hp阳性糖尿病胃轻瘫患者疗效及对血浆胃动素、胃泌素、内皮素影响。方法选择Hp阳性糖尿病胃轻瘫患者90例,随机分为三组(乌梅丸组、红霉素组、莫沙必利组),在控制血糖的基础上,三组分别给予乌梅丸、红霉素、莫沙必利口服,疗程30天,观察治疗前后症状,血浆胃动素、胃泌素及内皮素水平。结果经过30天治疗后,乌梅丸组总有效率为90.00%,明显高于红霉素组(70.00%)、莫沙必利组(73.33%),与其它两组比较差异有统计学意义(P<0.05);治疗前,乌梅丸组、红霉素组、莫沙必利组三组其胃泌素、胃动素、内皮素各指标在两两间差异无统计学差异(P>0.05)。治疗后,三者胃泌素、胃动素、内皮素值均有所下降,在胃泌素方面,以乌梅丸组下降明显,其与治疗前比较有显著性差异(P<0.05),与红霉素组、莫沙必利组比较有显著性差异(P<0.05);在胃动素方面,三组与治疗前比较有显著性差异(P<0.05),治疗后三组两两比较无显著性差异(P>0.05);在内皮素方面,乌梅丸组、红霉素组与治疗前比较有显著性差异(P<0.05),其中乌梅丸组与红霉素组、莫沙必利组比较有显著性差异(P<0.05)。结论乌梅丸能降低Hp阳性糖尿病胃轻瘫患者血浆胃泌素、内皮素水平,对糖尿病胃轻瘫患者有较好的疗效。
Objective To investigate the influence of wumei pills on motilin, gastri and endothelin in DGP patients infected by Helicobacter pylori. Methods Ninety patients with positive lip were selected and randomly divided into three groups： wumei pill group, erythromycin group, mosapride group. The patients were treated with corresponding drugs for 30 days, the three groups were taken pre-and post-treatment for measuring symptoms, motilin （MTL）, gastrin （GAS）, and endothelin （ET） levels. Results The clinical effect in wumei pill group was 90.00%, significantly higher than 70.00% in erythromycin group, 73.33% in mosapride group after 30 days of treatment （P〈0.05）. The GAS, MTL, ET levels dropped in three groups after treatment. The GAS, ET levels in wumei pill group were significantly lower than those in the other two groups after treatment （P 〈0.05）. Conclusions Wumei pills can reduce gastrin and endothelin levels significantly in Hp positive patients with diabetic gastroparesis, which have a better clinical effect on patients with diabetic gastroparesis.
出处
《临床医学工程》
2013年第2期167-169,共3页
Clinical Medicine & Engineering
