摘要
目的:检测合并胃肠功能障碍的急诊重症患者血胃泌素(gastrin,GAS)水平和对急诊重症患者APACHEⅡ评分进行断面分析,探讨GAS水平在胃肠功能障碍发生早期的临床意义.方法:共84例患者入选,其中胃肠功能受损组23例,胃肠衰竭早期组22例,胃肠衰竭组39例,设同期健康体检者20例为对照组,84例患者在入院第1、3、5天进行血GAS水平检测和APACHEⅡ评分,按评分<15、15-25、>25进行断面分组.结果:除第5天胃肠衰竭组与胃肠衰竭早期组GAS水平两两比较无统计学意义外(q=2.456P=0.086),第1、3、5天各组GAS水平两两比较均有统计学差异,P<0.05;第1、3、5天GAS与胃肠功能障碍严重程度分组有显著相关性(r=0.855、0.895、0.682,P=0.000).按APACHEⅡ评分断面分组GAS水平总体比较有统计学差异,P<0.05;各组GAS水平两两比较均有统计学差异,P<0.05;各组GAS水平与APACHEⅡ评分有显著相关性(r=0.805,P=0.000).结论:急诊重症患者GAS水平与重症患者疾病严重程度相关,GAS水平可以早期提示胃肠功能障碍的存在和判定胃肠功能障碍严重程度.
AIM：To detect serum gastrin （GAS） levels and calculate APACHE Ⅱ score in emergency intensive care unit （EICU） patients with gastrointestinal dysfunction and to analyze the clinical significance of GAS levels in the occurrence of early gastrointestinal dysfunction. METHODS：Eighty-four patients were divided into three groups：gastrointestinal function impairment group （n = 23）, early gastrointestinal failure group （n = 22）, and gastrointestinal failure group （n = 39）. Twenty healthy persons were used as normal controls. Serum GAS levels were detected and APACHE Ⅱ scores were calculated on the 1st, 3rd, and 5th day after admission, and patients were divided into three groups based on APACHE Ⅱ score： 15, 15-25, and 25. RESULTS：Except that there was no significant difference in serum GAS levels between the gastrointestinal failure group and early gastrointestinal failure group on day 5 （q = 2.456, P = 0.086）, significant differences were noted at all time points in pairwise comparisons between various groups （all P 0.05）. There was a significant correlation between GAS levels and severity of gastrointestinal functional disorders at various time points （r = 0.855, 0.895, 0.682, all P = 0.000）. There was a significant difference in GAS levels among groups with different APACHE Ⅱ scores （P 0.05）, and pairwise comparisons of these groups also showed significant differences （all P 0.05）. GAS levels were significantly correlated with APACHE Ⅱ score （r = 0.805, P = 0.000）. CONCLUSION： Elevated GAS levels in early stage could help judge the presence and severity of early gastrointestinal dysfunction in EICU patients.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第35期3584-3587,共4页
World Chinese Journal of Digestology
关键词
胃泌素
多器官功能障碍综合征
胃肠功能障碍
应激
Gastrin
Multiple organ dysfunction syndrome
Gastrointestinal dysfunction
Stress
