摘要
计算了4种α-取代丙酸酯衍生物在β-环糊精衍生物气相色谱固定相上手性分离过程中的热力学参数,对手性拆分机理进行了探讨。实验结果显示随着温度的升高,样品的容量因子、手性选择因子和分离度都在逐渐降低。热力学参数表明,4种α-取代丙酸酯在固定相上的色谱保留及手性识别都为焓驱动过程,氢键力没有在手性识别中起到决定作用,而样品的母体结构和取代基团的性质则对手性识别有较大的影响。样品在固定相上的手性分离效率的驱动力主要来自于其对映异构体与固定相之间作用力的能量差异。
The enantioseparation mechanism of four propanoic acid esters with α-substitute, in capillary gas chromatography using β-cyclodextrin derivative stationary phase was evaluated based on thermodynamic method. It was found that the capacity factor, chiral selectivity factor and resolution of samples were all decreased while the separation temperature increased. The results indicated the hydrogen bonding action was not the key to the enantioseparation. By comparison, the host structures and character of samples had larger effect on enantioseparation. The thermodynamic mechanism indicated further that enantioseparation was enthalpy controlling process in the examined temperature range mainly. Moreover, the efficiency of enantioseparation was maybe due to the difference of interaction energy between the enantiomers and the stationary phase.
出处
《分析试验室》
CAS
CSCD
北大核心
2013年第3期1-4,共4页
Chinese Journal of Analysis Laboratory
基金
国家自然科学基金(81001595)资助
关键词
毛细管气相色谱
Β-环糊精衍生物
α-取代丙酸酯
热力学
拆分机理
Capillary gas chromatography
β-cyclodextrin derivative
Propanoic acid esters with α-substitute, thermodynamic method
Mechanism of enantioseparation
