摘要
目的探讨局部晚期鼻咽癌调强放疗同期化疗前多西泰索加顺铂加氟尿嘧啶方案诱导化疗中顺铂最大耐受剂量（MTD）及方案安全性、有效性。方法选取33例局部晚期鼻咽癌患者，通过剂量递增试验确立顺铂MTD并评价临床疗效及不良反应。结果多西泰索60mg／m2第1天、氟尿嘧啶550mg／m2第1～5天剂量下顺铂MTD为65mg／m2第1天，每3周重复下3、4级不良反应发生率分别为中性粒细胞降低67％，粒细胞缺乏性发热9％，腹泻21％，口腔黏膜炎6％。除剂量限制性毒性患者外，其余均完成了治疗。诱导化疗后有效率为97％，其中完全缓解率为21％。结论鼻咽癌流行地区每3周重复用多西泰索60mg／m2第1天、顺铂65mg／m2第1天、氟尿嘧啶550mg/m2第1～5天治疗局部晚期鼻咽痛患者是安全有效的。
Objective To investigate the maximum-tolerated dose （MTD） of cisplatin in docetaxel, cisplatin, and fluorouracil （TPF） induction chemotherapy followed by intensity-modulated radiotherapy （IMRT） and concomitant chemotherapy as well as the safety and short-term efficacy of TPF induction chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma （ NPC ）. Methods Thirty- three patients with locally advanced NPC were enrolled in this trial. The MTD of cisplatin was determined by dose escalation study, and the short-term efficacy and toxicities were evaluated. Results When the doses of doeetaxel and fluorouracil were 60 mg/m2 dl and 550 mg/m2 dl--5, respectively, the MTD of cisplatin was 65 mg/m2 dl. In this regimen （repeated every 3 weeks）, grade 3--4 toxicities included neutropenia （67%）, febrile neutropenia （9%）, diarrhea （21%）, and oral mucositis （6%）. Except those who experienced dose-limited toxicity, other patients completed the whole treatment schedule. After TPF induction chemotherapy, the overall response rate was 97%, and the complete response rate was 21%. Conclusions In the endemic areas of NPC, induction chemotherapy with docetaxel （60 mg/m2 dl ） , cisplatin （65 mg/m2 dl ）, and fluorouracil （550 mg/m2 dl--5）, which is repeated every 3 weeks, is oroved safe and effective for Asian natients with locallv advanced NPC.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2013年第2期129-132,共4页
Chinese Journal of Radiation Oncology
关键词
鼻咽肿瘤
化学疗法
化学疗法
新辅助
不良反应
剂量递增试验
Nasopharygeal neoplasms/chemotherapy
Chemotherapy, neoadjuvant
Adverse effect
Dose escalation trial
