摘要
目的在三维适形放射治疗鼻咽癌时,比较常规分割和大分割的近期疗效及急性反应。方法将2005年12月—2010年10月我院收治的60例鼻咽癌患者按随机数字表法分为常规分割放疗组(对照组)30例和后程大分割放疗组(治疗组)30例,比较两组的疗效及放射反应。结果放疗结束时评价,对照组和治疗组的完全缓解(CR)率分别为80%和90%(P>0.05)。放疗结束后3个月评价,对照组和治疗组鼻咽及颈部残留者均达到CR,两组鼻咽癌的CR率均达到100%(P>0.05)。对照组0～4级急性黏膜反应分别为0、0、4、25和1例,治疗组分别为0、0、3、26和1例,对照组及治疗组的中重度(3、4级)急性黏膜反应发生率分别为83%%和90%(P>0.05)。对照组和治疗组分别有4例和3例(P>0.05),放疗时间延长超过1周。结论后程大分割放疗能够取得不低于常规分割的近期疗效,且不增加急性反应、不延长放疗时间。
Objective To compare the short - term effects and acute reactions between later course hypofractionated three dimensional eonformal radiotherapy （3D CRT） and conventional fractionated radiotherapy （CFRT）. Methods Sixty pa- tients with primary nasopharyngeal carcinoma were divided randomly into groups control （ given CFRT）, treatment （ given 3D CRT）, 30 in each. Therapeutic effects and radioreaction were compared between 2 groups. Results By the end of radiothera- py, the complete remission （CR） rate was 80% in control group, 90% in treatment group （P 〉0. 05）. CR was 100% in 2 groups 3 months after radiotherapy （P 〉 0. 05）. The patients with grades 0 , 4 acute mucositis were 0, 0, 4, 25, 1 in control group, 0, 0, 3, 26, 1 in treatment group, and the incidence of moderate or severe acute mucositis （grades 3, 4） was 83% in control group and 90% in treatment group （ P 〉 0.05 ）. The radiotherapy time extended over 1 week in 4 of control group and 3 of treatment group （P 〉 0. 05 ）. Conclusion Late - course hypofractionated 3 D CRT has as short - term effect good as CFRT, not increasing acute reaction or extending radiotherapy time.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第5期553-555,共3页
Chinese General Practice
基金
江西省卫生厅课题(20073134)
关键词
鼻咽肿瘤
三维适形放射治疗
近期疗效
Nasopharyngeal neoplasms
Three dimensional conformal radiotherapy
Short- term effect
