摘要
Wnt信号传导通路与肿瘤的关系是近年来肿瘤研究的热点,该通路包含许多信号成员,其中BCL9是近年来该通路上发现的新的癌基因,其在多种Wnt信号通路失调肿瘤中的异常表达表明其与肿瘤的发生、发展有密切关系.而针对Wnt信号通路不同基因靶点的高特异性基因药物开发以及肿瘤的分子诊断也相继出现,尤其是针对BCL9与β-catenin作用界面的小分子抑制剂基因药物的开发更是引起广泛的注意.现就BCL9及其与肿瘤的关系和BCL9基因为靶点的肿瘤基因治疗等三方面做一综述.
The relationship between Wnt signal transduction pathway and tumor has become a hot spot in cancer research. Wnt signaling pathway contains many members, BCL9 is a novel oncogene in this pathway in recent years, its abnormal expression in a variety of tumors of the Wnt signaling pathway disorders show that BCL9 is closely related to oncogenesis. The development of high-specific genes drug for different gene targets in Wnt signaling pathway and the molecular diagnostics of tumors have appeared. The extensive at- tention is caused by gene drug development of small molecule inhibitors to specifically disrupt the fl-eatenin/ BCL9 interface. Therefore, BCL9 and its relationship with tumor, and BCL9 gene as a target for cancer gene. therapy are reviewed.
出处
《生命科学研究》
CAS
CSCD
北大核心
2013年第1期86-89,共4页
Life Science Research
