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鼠双微染色体2基因对鳞状细胞癌预后评估的研究进展 被引量:2

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摘要 鼠双微染色体2(murinedoubleminute2,MDM2)是1991年从一个含有双微体(murinedoublemimut,MDM)的自发转化的BAI,B/ST3DM细胞中克隆出来的一个高度扩增的基因,其产物MDM2蛋白是p53的重要负性调节因子,通过p53途径、非p53依赖途径等多种方式调节细胞异常增殖和凋亡,在肿瘤发生、发展中起重要作用。
出处 《重庆医学》 CAS CSCD 北大核心 2013年第8期952-954,共3页 Chongqing medicine
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